Protein Info for HMPREF1078_RS15295 in Parabacteroides merdae CL09T00C40

Annotation: adenosylmethionine--8-amino-7-oxononanoate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 TIGR00508: adenosylmethionine-8-amino-7-oxononanoate transaminase" amino acids 14 to 423 (410 residues), 594.9 bits, see alignment E=3.3e-183 PF00202: Aminotran_3" amino acids 27 to 421 (395 residues), 436.4 bits, see alignment E=4.6e-135

Best Hits

Swiss-Prot: 69% identical to BIOA_HAEIN: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 84% identity to pdi:BDI_1914)

MetaCyc: 61% identical to adenosylmethionine-8-amino-7-oxononanoate aminotransferase (Escherichia coli K-12 substr. MG1655)
Adenosylmethionine--8-amino-7-oxononanoate transaminase. [EC: 2.6.1.62]

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.62

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>HMPREF1078_RS15295 adenosylmethionine--8-amino-7-oxononanoate transaminase (Parabacteroides merdae CL09T00C40)
MTTEELLHFDREHIWHPYTSTIDPLPVYPVERAEGVTITLKDGRKLIDGMSSWWAAVHGY
NHPVLNAAAKAQLNKMSHIMFGGFTHEPAVELAAKLFPLLPPSMQKIFFADSGSVAVEVA
MKMAIQYWQSQGKQKKYAFATIRSGYHGDTWHAMSVCDPVTGMHGIFSGSLPVQYFIPQP
SVRFEEKWDEKAIEPLKDLFEKHAEEIAALILEPVVQGAGGMYFYSPTFLIAARELCDRY
QVLLIFDEIATGFGRTGQLFAWEWAGVEPDIMCIGKALTGGYMTLSATVTSTPVADMICS
GEAGCFMHGPTFMGNPLACAIASASVSLLLESGWQEKVKAIESQLREELAPAASFPDVQE
VRVLGAIGVIEMKEPVNMAVLQKRFVEEGIWVRPFGKLVYLMPPFIIQKEELSKLTKGLL
TVLDSK