Protein Info for HMPREF1078_RS14935 in Parabacteroides merdae CL09T00C40

Annotation: N-acetylmuramic acid 6-phosphate etherase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 271 TIGR00274: N-acetylmuramic acid 6-phosphate etherase" amino acids 7 to 257 (251 residues), 313.4 bits, see alignment E=6.4e-98 PF13580: SIS_2" amino acids 40 to 164 (125 residues), 29 bits, see alignment E=1.5e-10 PF22645: GKRP_SIS_N" amino acids 46 to 150 (105 residues), 69.4 bits, see alignment E=3.4e-23 PF01380: SIS" amino acids 127 to 205 (79 residues), 38.2 bits, see alignment E=1.8e-13

Best Hits

Swiss-Prot: 79% identical to MURQ_BACFN: N-acetylmuramic acid 6-phosphate etherase (murQ) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K07106, N-acetylmuramic acid 6-phosphate etherase [EC: 4.2.-.-] (inferred from 80% identity to bhl:Bache_0402)

MetaCyc: 48% identical to N-acetylmuramic acid 6-phosphate etherase (Escherichia coli K-12 substr. MG1655)
RXN0-4641 [EC: 4.2.1.126]

Predicted SEED Role

"N-acetylmuramic acid 6-phosphate etherase"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.-.- or 4.2.1.126

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (271 amino acids)

>HMPREF1078_RS14935 N-acetylmuramic acid 6-phosphate etherase (Parabacteroides merdae CL09T00C40)
MSFIKITEQNSLYNDLERKSVRDLLEDINTEDQKVALAVRETIPKIEELVLQIVPRMKQG
GRIFYLGAGTSGRLGVLDASEIPPTFGMPSTLIVGLIAGGDTALRNPVENAEDDEERGWQ
ELLEHRVNTKDTVIGIAASGTTPYVIGALRKAREQGILTASISSNPDSPMAMEADIAIEM
IVGPEFVTGSSRMKSGTGQKMILNMISTSVMIRLGRVKGNRMVNMQLTNQKLIDRGTRMV
AEELNLPYNQSRHLLLMYGSVQEAVEAYRKA