Protein Info for HMPREF1078_RS14930 in Parabacteroides merdae CL09T00C40
Annotation: lactonase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 35% identical to 6PGL_BACSU: 6-phosphogluconolactonase (pgl) from Bacillus subtilis (strain 168)
KEGG orthology group: None (inferred from 54% identity to bfs:BF1038)Predicted SEED Role
"6-phosphogluconolactonase (EC 3.1.1.31)" in subsystem Entner-Doudoroff Pathway or Pentose phosphate pathway (EC 3.1.1.31)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- pentose phosphate pathway (8/8 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
- Entner-Doudoroff pathway I (8/9 steps found)
- pentose phosphate pathway (oxidative branch) I (3/3 steps found)
- heterolactic fermentation (13/18 steps found)
- formaldehyde oxidation I (3/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 3.1.1.31
Use Curated BLAST to search for 3.1.1.31
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (353 amino acids)
>HMPREF1078_RS14930 lactonase family protein (Parabacteroides merdae CL09T00C40) MQKDSELFLFVGSYAGATDPGINLFRFDVEKGTAVPVKSLSGIQDPSYLTVSRDGKFVYS VSETAVPDAKVCAYSFDKQTGTLSLLNEQHTDGSAPCYIWVDSKHRMAVTANYNGGSISV FSISADGALLPAEVYAYEGGRPGAERQAVPHLHCVYASPDENYLYANDLGTDRIYKYEIV ASDKGLSLREGTPASFSLPVGEGPRHTVFHPNGKWAYLISELSGRVALMYYDKGNLTPVR FVEADTLHVSGSADIHITPDGRFLYASNRLKGDGIAIFSIDLENGQLTKIGYQLTGIHPR NFVITPNGKFLLCACRDSHIVQVYEIDKQSGLLKDTGKDIRVSKPVCLKFTDM