Protein Info for HMPREF1078_RS14650 in Parabacteroides merdae CL09T00C40

Annotation: M3 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 696 PF01432: Peptidase_M3" amino acids 230 to 680 (451 residues), 473.2 bits, see alignment E=6.7e-146

Best Hits

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 76% identity to pdi:BDI_0207)

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

Compare fitness of predicted isozymes for: 3.4.15.5

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (696 amino acids)

>HMPREF1078_RS14650 M3 family metallopeptidase (Parabacteroides merdae CL09T00C40)
MKQNRENPFFETYRTPFGTPPFDQIETEQYEPAFDEGIWQLDEEVRAIADNTELPTFENT
IIALERSGKLLDKVISAFFNVLNAEADDEMMDISQRVSPKLSESSNNIYLNEQLFARVKS
VYDRKDELHLPMEDARLLEKTFEAFCARGAALGPEEKEKYRKLSSELSLLSLTFDQNALK
DKNRYELLLTKEDELEGLPESIREAAALRAKEKGKTGWLFNLSAPSYVPFMRYSALRGLR
EKMYREYMSIGNKGDEYDNKEIIREIVNIRLEIARLMGYTNYADYKLKHTMAKTPARVYK
LLNELLDAYKPVARNEYETVQRFASETEKENITVMPWDWSYYSEKLKDIRFNVNDEMTRP
YFELNHVKKGVFGLATQLYGITFKENKEIPVYHPEVEAYEVYDADGKFLSILYTDFHPRD
GKQSGAWMNSIKEQYRDQDGKDSRPQIIIVMNFTRPTETKPSLLTFDEVNTLLHEFGHAL
HGMFAEGSYASLSGTNVYRDFVELPSQLMENWLTEKEFLDQIAIHYKTGEKIPQELVQKL
IDASNFNAGYACCRQLSFGFLDMAWHTRTEPFGEDVISFEKEAWKQTVIVPEVPGTLMSS
SFGHIFSGGYSAGYYGYKWAEVLDADAFSVFKETGIFNRETARSFRKNILSKGGTEDPDI
LYKRFRGKDAEIGALLKRNGIEPGGPSASVQSRMQV