Protein Info for HMPREF1078_RS14540 in Parabacteroides merdae CL09T00C40

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 TIGR00557: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA" amino acids 8 to 329 (322 residues), 376.2 bits, see alignment E=7.7e-117 PF04166: PdxA" amino acids 34 to 326 (293 residues), 378.2 bits, see alignment E=1.4e-117

Best Hits

Swiss-Prot: 64% identical to PDXA_BACTN: 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 87% identity to pdi:BDI_0187)

Predicted SEED Role

"4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.262)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.262

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (366 amino acids)

>HMPREF1078_RS14540 4-hydroxythreonine-4-phosphate dehydrogenase PdxA (Parabacteroides merdae CL09T00C40)
MEERLVKVGITHGDINGIGYEVILKTLSDTRIAELCTPVIYGSSKIAAYHRKVLELPAVN
LSIIAQAEDAGANRVNIINCVDDETKVELCQSTTAAGEAAYLALEAAVTDLKRGAVDVLV
TAPINKHNIQNEQFHFPGHTEYLEQCFGGLGKKALMILMKDNLRVALVTGHIPLAQVASK
ITVEDIVSKLRIFNQSLRQDFGIVRPRIAVLALNPHAGDAGLLGKEEEEIIIPAIQEAEK
KGVMSFGPYAADGFFGSQVYDKFDGVLAMYHDQGLAPFKTLAMDDGVNYTAGLSIVRTSP
AHGTAYDIAGQNVASEESFRQALYAALDIYRNRIRYREATANPLRKQYFDKGGDNEKLDL
TKEEDE