Protein Info for HMPREF1078_RS14525 in Parabacteroides merdae CL09T00C40

Annotation: SurA N-terminal domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 712 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details PF13624: SurA_N_3" amino acids 4 to 154 (151 residues), 60 bits, see alignment E=6.6e-20 PF13623: SurA_N_2" amino acids 4 to 152 (149 residues), 146.5 bits, see alignment E=1.3e-46 PF13145: Rotamase_2" amino acids 239 to 354 (116 residues), 40.1 bits, see alignment E=1.5e-13 PF13616: Rotamase_3" amino acids 345 to 458 (114 residues), 112.7 bits, see alignment E=3.6e-36 PF00639: Rotamase" amino acids 364 to 456 (93 residues), 56.8 bits, see alignment E=9.3e-19

Best Hits

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 79% identity to pdi:BDI_0184)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (712 amino acids)

>HMPREF1078_RS14525 SurA N-terminal domain-containing protein (Parabacteroides merdae CL09T00C40)
MATLEKIRSKAGLLVLVVGVALFAFIIGDFLNSGSTYFRQSQETVAEVDGEVIKIQEFQD
RVDEMTEMYKMQTGSTSLPEEYQTQIRQSVFDGMVQDIVLNEATSELGMGVGPEELFDMV
QGENISPMIQQMQMFVNPQTGAFDKTALLNFLKTIDDDNIANYPADQQAQLLQGRQFWMF
WEKNIKRQRLEQKYTTLLSKAVSANKLDAKDAFDGSAVSSDIVYAMQSYASIPDSTIQVS
KSDIEKLYNQRKELFKQKEGKVIKYIAVDIRPSKEDYDKASAEIESLKSELATSEKVADL
VTENSEIPYMDAFFTENALDPEMKQFVKTANVGDVYGPVFENDKYRLFKLVDKTVAPDSV
KVSHIMLANTGDEAAIKAKADSLLNVLKKGGDFVALAKEYSADQAAEKGGELGWFTEATA
LRGVNDDFKKAVFSTPVNDYSIVKSLYGTHIIKVTDKTTNVDKYKVADIDMTVSPSTKTY
GNIYNELNQFISKNQNIDKLDDAAKEAGYNLLSNVTVTANDQLLGSIKNSRPVIRWAFQN
NKGDISEIFECDDKFVIAAIQGTLPEGYRSLESVTPMLKSELIAQKKGEKIAQDLSAKNL
SSVDAYAQAMNSSADSVKFVSFATRRIAGIGVEPKLNAMVSLAQKDQLSAPVVGNNGVYV
FKVYEQNKDAKNYDEAAEIKALDASNAYRFGFQAIQSLVNKADVEDNRIRFY