Protein Info for HMPREF1078_RS14380 in Parabacteroides merdae CL09T00C40

Annotation: sigma-54 dependent transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 PF00072: Response_reg" amino acids 4 to 110 (107 residues), 89 bits, see alignment E=8.4e-29 PF00158: Sigma54_activat" amino acids 139 to 306 (168 residues), 237 bits, see alignment E=3.4e-74 PF14532: Sigma54_activ_2" amino acids 140 to 310 (171 residues), 82.7 bits, see alignment E=1.1e-26 PF07728: AAA_5" amino acids 162 to 281 (120 residues), 32.5 bits, see alignment E=2.9e-11 PF00004: AAA" amino acids 163 to 284 (122 residues), 31.7 bits, see alignment E=6.7e-11 PF07724: AAA_2" amino acids 163 to 288 (126 residues), 32.3 bits, see alignment E=3.6e-11 PF02954: HTH_8" amino acids 403 to 440 (38 residues), 51.4 bits, see alignment 2.6e-17

Best Hits

KEGG orthology group: None (inferred from 82% identity to pdi:BDI_0114)

Predicted SEED Role

"Response regulator of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (442 amino acids)

>HMPREF1078_RS14380 sigma-54 dependent transcriptional regulator (Parabacteroides merdae CL09T00C40)
MGKVLIIDDEKQILSLLSRIIGLEGYEVFQATNCKVGIKQLEQNDPEVVLCDVCLPDGSG
VELVSELKRLRPLSEVILLTAHGNIPDGVQAIKNGAFDYITKGDDNNKILPLIAKAMEKA
TVAYSQQKAVGKQYSFATVIGRSPAIEEAVSLARKVAATDVPVLLTGETGTGKEVFAQSI
HQHSSRSDKAFVAINCSSFSRDLLESEMFGHKAGAFTGALKETKGLFEEADNGTIFLDEI
GEMAFDLQAKLLRILETGEFLKIGDTKPVKVNVRVIAATNRDLAKEIADGHFREDLFYRL
SVFHIHLPPLRERVDDIPLHVEAFVSALSSKIGKTIRTISPDYVRILKRYPWKGNVRELR
NVVERSLIISDGDTLTADTLPLTIQNPQDNTDSSYSGFDLDGVEKMHIQKVLKYTNGNKT
ETSRLLGIGLTTLYRKIEEYGL