Protein Info for HMPREF1078_RS13185 in Parabacteroides merdae CL09T00C40

Annotation: cytochrome c biogenesis protein CcdA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 697 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 241 to 265 (25 residues), see Phobius details amino acids 286 to 309 (24 residues), see Phobius details amino acids 320 to 343 (24 residues), see Phobius details amino acids 363 to 390 (28 residues), see Phobius details amino acids 401 to 422 (22 residues), see Phobius details amino acids 439 to 461 (23 residues), see Phobius details amino acids 471 to 489 (19 residues), see Phobius details amino acids 505 to 526 (22 residues), see Phobius details PF11412: DsbD_N" amino acids 35 to 146 (112 residues), 34 bits, see alignment E=5.6e-12 PF02683: DsbD" amino acids 249 to 438 (190 residues), 57 bits, see alignment E=5e-19 PF13899: Thioredoxin_7" amino acids 556 to 616 (61 residues), 45.2 bits, see alignment 1.7e-15

Best Hits

KEGG orthology group: None (inferred from 84% identity to pdi:BDI_3793)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (697 amino acids)

>HMPREF1078_RS13185 cytochrome c biogenesis protein CcdA (Parabacteroides merdae CL09T00C40)
MKKLFSTLMLVLVALTVQAQILQPVKWKIQLNDSGSAEKEIVFTATADKGWHLYDQDLPE
GGPVSTSFTFETLKGAELIGKPTSSVKPTTVYDELFAMNLRWYPGTVSFTQKFKVTDPAK
FKAEGEVEFMACNDETCLPPDRVSFSFDKKNIKMTAAAETVVEKPEVEQDDVTAVQPDTE
KVVEEVAELKAPAPVTNKDKAENRPVRASNELTDDAALWTPVIDQLKAFGDTTVSATDTS
WLFIFFAGFLGGLIALLTPCVWPMIPMTVSFFLKRTKDRKKAIRDAMTYGLSIIVIYLVM
GLLITGIFGASALNDLSTNAIFNIIFFLLLVVFAISFFGAFEMVLPSSWTNKLDTKADST
TGIISIFFMSFTLVLVSFSCTGPIIGTLLVQAASMGTAVGPAIGMFGFALALSIPFSLFA
IFPNMLQSMPKSGGWLNSVKVVLGFLELALALKFLSVADLAYGWRLLDREVFIVLWIVIF
ILLGCYLLGKIKFSHDSDLPYVSVPRLFMAIISFSFAVYMVPGLWGAPLKAISAFAPPLY
TQDFNLYNSEVHAAFDDYETGMAYAKKVNKPVMIDFSGFGCVNCRKMEASVWTDPKVKQI
LENDYVLITLMVDDKTKLPQPITIEEHGKTRKLKTIGDKWSYLQRSKFGANAQPFYILLN
AEGKPLGPSYAFNESVPDYIKFLENGLKVFKEQEKNK