Protein Info for HMPREF1078_RS13180 in Parabacteroides merdae CL09T00C40
Annotation: nucleoside triphosphate pyrophosphohydrolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 42% identical to MAZG_HAEIN: Nucleoside triphosphate pyrophosphohydrolase (mazG) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG orthology group: K02428, nucleoside-triphosphate pyrophosphatase [EC: 3.6.1.19] (inferred from 91% identity to pdi:BDI_3792)MetaCyc: 40% identical to nucleoside triphosphate pyrophosphohydrolase (Escherichia coli K-12 substr. MG1655)
Nucleotide diphosphatase. [EC: 3.6.1.9]
Predicted SEED Role
"Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8)" (EC 3.6.1.8)
MetaCyc Pathways
- pyrimidine deoxyribonucleotides dephosphorylation (2/3 steps found)
- dZTP biosynthesis (3/5 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (12/18 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (5/9 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (4/9 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis II (2/7 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (7/14 steps found)
- tunicamycin biosynthesis (2/9 steps found)
KEGG Metabolic Maps
- Drug metabolism - other enzymes
- Nicotinate and nicotinamide metabolism
- Pantothenate and CoA biosynthesis
- Purine metabolism
- Pyrimidine metabolism
- Riboflavin metabolism
- Starch and sucrose metabolism
Isozymes
Compare fitness of predicted isozymes for: 3.6.1.9
Use Curated BLAST to search for 3.6.1.19 or 3.6.1.8 or 3.6.1.9
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (261 amino acids)
>HMPREF1078_RS13180 nucleoside triphosphate pyrophosphohydrolase (Parabacteroides merdae CL09T00C40) MATKQEKMEAFGQLLDILDELRVKCPWDRKQTNESLRTNTIEETYELCDAIMKDDNNNIK KELGDLLLHIVFYAKIGEEKAAFDIKDVCDSLCQKLIYRHPHVFGNAQAETAGKVEQSWE QLKLKEKGGNKTVLEGVPTSLPSVVKAHRIQDKARNVGFDWEQRDQVWDKVHEEFTELKT EIDKMDADKMEAEFGDLFFSLINAARLYKINPDNALERTNQKFTRRFNYLEEHTIKEGKS LKDMSLEEMDRIWNEAKAKGL