Protein Info for HMPREF1078_RS13135 in Parabacteroides merdae CL09T00C40
Annotation: adenylosuccinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 90% identical to PURA_PARD8: Adenylosuccinate synthetase (purA) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
KEGG orthology group: K01939, adenylosuccinate synthase [EC: 6.3.4.4] (inferred from 90% identity to pdi:BDI_3782)MetaCyc: 46% identical to Ade12 (Saccharomyces cerevisiae)
Adenylosuccinate synthase. [EC: 6.3.4.4]
Predicted SEED Role
"Adenylosuccinate synthetase (EC 6.3.4.4)" in subsystem CBSS-262719.3.peg.410 or Purine conversions (EC 6.3.4.4)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (18/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (20/26 steps found)
- adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (4/5 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (5/7 steps found)
- superpathway of purine nucleotide salvage (10/14 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Biosynthesis of alkaloids derived from histidine and purine
- Purine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.4.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (423 amino acids)
>HMPREF1078_RS13135 adenylosuccinate synthase (Parabacteroides merdae CL09T00C40) MKVDVLLGLQWGDEGKGKVVDVLTPNYDVITRFQGGPNAGHTLEFNGEKYVLRSIPSGIF QGGKVNVIGNGVVLDPLLFQQEAEALAASGHDLTKQLCISKKAHLILPTHRILDAAYEAA KGSGKIGTTGKGIGPTYTDKISRNGLRVGDLLHNFDEKYAAAKARHEAILRSLNYEYDIT ELEAQWFKALDYLKQFRLIDSEHVINNYLKEGKSVLAEGAQGTMLDIDFGSYPFVTSSNT ICAGCCTGLGVSPRNIGEVYGIFKAYCTRVGSGPFPTELFDETGSKIRQIGHEYGAVTGR ERRCGWIDLVALKYAIMINGVTKLIMMKSDVLDGFETVKACIAYKVNGEETTEFPFEINE GIEPVYVEMPGWNVDMTKMQSEDEFPEEFNAYISFLEEELEVPIKIVSVGPDREQTIVRY TEE