Protein Info for HMPREF1078_RS13055 in Parabacteroides merdae CL09T00C40

Annotation: low molecular weight protein-tyrosine-phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 43% identical to PTPA_STRCO: Low molecular weight protein-tyrosine-phosphatase (ptpA) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

KEGG orthology group: K01104, protein-tyrosine phosphatase [EC: 3.1.3.48] (inferred from 79% identity to pdi:BDI_2297)

Predicted SEED Role

"Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48)" in subsystem LMPTP YfkJ cluster or LMPTP YwlE cluster (EC 3.1.3.48)

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.48

Use Curated BLAST to search for 3.1.3.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (169 amino acids)

>HMPREF1078_RS13055 low molecular weight protein-tyrosine-phosphatase (Parabacteroides merdae CL09T00C40)
MMEEKKGEYKILFVCLGNICRSPSAEAVMKKLVQDAGLDGRIKIDSAGIIGYHAGEKADP
RMRSHAARRGYKLDSVSRPVCTEDFFDFDLIIGMDNRNIDDLKRKAPDLESVEKIHQMTE
YSQNKLYDHVPDPYYSGAEGFELVLDLLEDACAGLLDELVQFISSNPDN