Protein Info for HMPREF1078_RS12815 in Parabacteroides merdae CL09T00C40

Annotation: NAD-dependent deacylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02146: SIR2
  • amino acids 10 to 180 (171 residues), 147.7 bits, E=1.8e-47

Best Hits

Swiss-Prot: 66% identical to NPD_BACTN: NAD-dependent protein deacylase (cobB) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K12410, NAD-dependent deacetylase [EC: 3.5.1.-] (inferred from 85% identity to pdi:BDI_2710)

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.-

Protein Sequence (231 amino acids)

>HMPREF1078_RS12815 NAD-dependent deacylase (Parabacteroides merdae CL09T00C40)
MKKKLVVLTGAGMSAESGISTFRDSDGLWEKYRVEDVATPEGFAADPELVLNFYNQRRRE
LLNTKPNAGHIGLADLEQEFDVHIITQNIDNLHERAGSSHVIHLHGELLKACSIRDLNTT
YDISPENPDLHIGDKDPHGVQLRPFIVWFGEAVPMIDPAIRLVEDCDIFVVIGTSLNVYP
AAGLLNYVRHGQTIYLIDPKEVKAYRNDIRFIRKGASEGVKELKELLLQNH