Protein Info for HMPREF1078_RS12625 in Parabacteroides merdae CL09T00C40

Annotation: hybrid sensor histidine kinase/response regulator transcription factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1322 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 773 to 793 (21 residues), see Phobius details PF07494: Reg_prop" amino acids 36 to 58 (23 residues), 18.2 bits, see alignment (E = 8.5e-07) amino acids 82 to 102 (21 residues), 16 bits, see alignment (E = 4.3e-06) amino acids 349 to 370 (22 residues), 16.4 bits, see alignment (E = 3.2e-06) amino acids 528 to 547 (20 residues), 19.3 bits, see alignment (E = 3.7e-07) PF07495: Y_Y_Y" amino acids 702 to 765 (64 residues), 53.7 bits, see alignment 6.3e-18 PF00512: HisKA" amino acids 820 to 881 (62 residues), 43.5 bits, see alignment 1.1e-14 PF02518: HATPase_c" amino acids 932 to 1043 (112 residues), 68.4 bits, see alignment E=2.8e-22 PF00072: Response_reg" amino acids 1075 to 1185 (111 residues), 81.2 bits, see alignment E=2.5e-26 PF12833: HTH_18" amino acids 1241 to 1319 (79 residues), 66.9 bits, see alignment 6.6e-22

Best Hits

Predicted SEED Role

"Two-component system sensor histidine kinase/response regulator, hybrid"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1322 amino acids)

>HMPREF1078_RS12625 hybrid sensor histidine kinase/response regulator transcription factor (Parabacteroides merdae CL09T00C40)
MKHLKLILSILFIFCLTRTYADDSNYLFRHYQVENGLSDNMATCCVQDRKGYIWIGTRDG
LNRFDGYTFKVFRNDPDETETLGSNWITCLGCDMNGDLWVGTLSGLYQYDDEKESFRHIP
FTADKGIDIFQFDKDNKLWILMDGNLIRFNTEDSQFRIFAPEDNQSYTSFCITRENSIWI
GSSDGLISLLNPEDETMESHNVFAHSSPNTPRKLSMLYPSPTTDRIYIAFEHDDVKIFDP
ATRDYQDLNIQKINQLTILINSFLEKDKDELWIGTDSGLFIYKVNTGECTRIRQDPLDPY
ALSSHFISAFCRDRENGIWICFHQNGLNYYSPFRPFHVHYPWDGQYSMKGEVIRDICTDI
YGNIWVGTEDAGINCLEKKTGTFTNYQPVPGGNGLSHTNIRGLAASGDRLWIGHVIHGID
LMDIKTRKVIKHYNLLKDSLTVKNSTVRCIKVLQEGQVYVGTDDGIYKYDFLNDRFLYAP
QFPPFAVNCIYEDRLGRIWTGMFNRSFYYNPISNTGMYLPYDKLNTQRHNFVNDACEDKD
GNMWFATVEGVIKYDFQTGESLHYTVKNGMPSNVAFRILPDENETLWISTANGLVSLETG
TGKITTYTESHGLITRQFNDNSAFKDNEGTFYFGSVKGFIHFKPSEVIPAAEKMNVHLGS
LEIQNEAGEKRIINSSAESEAKKITLTYKQSTFSINFSALNFIAPKSIQYAYRMGNMDKE
WIPIGERNTVYFAELHPGDYTFEVRAANLSNNWSDTPTRLNITVLPPWWASTPAYASYIV
VTLAIIVGFFWSWRRKTKRAMAYNMQLFEDQKEKELYQAKIDFFINIAHEIRTPLTLIKN
PLERLLKSDKIGEKENKSLTLMDKNVSRLLSLVNQLLDFRKTEIEGYRLSFVRTEIVSLL
NDTAKRFQESATAHNLLLNLDLSLPELYVFVDKEAITKIFSNLFTNAIKYASGSIIIRLQ
LSPDYETFTIDFINDGTPIPAELKEKIFEPFFRVKEGATDKPGTGLGLPLARSLAEMHHG
SLQLETFADSSSMTMFRLTLPVKLPESIKQTEEEAITQTVPQKIEFVHDESRPTILIVED
NKEMAVFIADEVNQLYNVEIAGNGAEAITLLKKHSIQLIISDVMMPVMDGFALLKEVKTE
IEFSHIPVILLTAKNTIQSRLEGLELGADAYLDKPFSTNLLMAQISNLISNRDNIRKFYF
NSPIANMKSMAYTKADESFLEKLNEIINEHIGNPALDVNMIADLMHLSRPTLYRKIRAIS
DLTPNELIKISRLKKAAELLIQGNMKIYEISEATGFSSQSYFWSAFIKQFGMSPSNYAKE
NK