Protein Info for HMPREF1078_RS12530 in Parabacteroides merdae CL09T00C40

Annotation: anaerobic ribonucleoside triphosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 735 PF03477: ATP-cone" amino acids 4 to 88 (85 residues), 79.6 bits, see alignment E=2.1e-26 PF13597: NRDD" amino acids 113 to 734 (622 residues), 679.8 bits, see alignment E=3.6e-208 TIGR02487: anaerobic ribonucleoside-triphosphate reductase" amino acids 113 to 734 (622 residues), 596.4 bits, see alignment E=2.9e-183

Best Hits

KEGG orthology group: K00527, ribonucleoside-triphosphate reductase [EC: 1.17.4.2] (inferred from 91% identity to pdi:BDI_3407)

Predicted SEED Role

"Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)" in subsystem Ribonucleotide reduction (EC 1.17.4.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (735 amino acids)

>HMPREF1078_RS12530 anaerobic ribonucleoside triphosphate reductase (Parabacteroides merdae CL09T00C40)
MIQTVIKRDGRIVGFNEEKIATAIRKAMLHTENGEDRELVRQITDHISFKGDSQMTVEAI
QDAVELELMNSSRKDVAQKYIAYRNQRSIARKAKTRDMFLEIINIKSNDITRENANMNAD
TPAGMMMKFSSETTKPFVDDYLLSEEVKEAVENNYLHIHDKDYYPTKSLTCVQHPLDHIL
KYGFSAGHGESRPAKRIETASILGCISLETAQNEMHGGQAIPAFDFYLAPYVRNSFIEEI
KNLEELNGQNYSHLYQQKLDDYVNRPLEGLSGDERIIQHAVNKTVSRVHQSMEAFIHNMN
TIHSRGGNQVVFSSINYGTDTSAEGRCIIREILKSTYRGVGNGETAIFPIQIWKKKRGVS
YLPEDRNYDLYQLACKVTARRFFPNFLNLDATFNQSEDWRADDPQRYMHEVATMGCRTRV
FENRFGPKTSIGRGNLSFSTINIVRLAIECMHIENKEERIAQFFAKLDHMLDITARQLHE
RMEFQKTAYAKQFPLLMSSLWLGSEKLKPNDTIAPVINQGTLGIGFIGLAECLVALTGKH
HGEDAASQELGLKIVSYIRNRANQFSEEYQHNYSVLATPAEGLSGKFTRRDRKKFGSLPG
ITDRDYYTNSNHVPVYYKCSARHKAEVEAPYHEMTRGGHIFYVEMDGDATHNPEVIMQVV
DMMDRYNIGYGSVNHNRNRCLDCGYENAETHLEKCPKCGSIHLDKLQRITGYLVGTTDRW
NKAKLAELNDRVVHN