Protein Info for HMPREF1078_RS12005 in Parabacteroides merdae CL09T00C40

Annotation: VapE family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 703 PF08800: BT4734-like_N" amino acids 54 to 186 (133 residues), 99.3 bits, see alignment E=3e-32 PF05272: VapE-like_dom" amino acids 406 to 616 (211 residues), 117.1 bits, see alignment E=1.2e-37 PF12990: DUF3874" amino acids 620 to 680 (61 residues), 47.3 bits, see alignment 3.1e-16

Best Hits

Predicted SEED Role

"putative helicase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (703 amino acids)

>HMPREF1078_RS12005 VapE family protein (Parabacteroides merdae CL09T00C40)
MKITQLRGDLAAFRNLELSIVLNAMKTENSRKPVTTLRQNIPYLTPGIKSLAAEKIPVVL
FGVTLKRDDERIGVATYAGLVLLSIGNLIDYAEAAAIRDRAAGFPQTLASFVGSSGRSVK
IVVPFTLSDGSLPKTERHMRLFHTHACLRAGRYYEAQLQLPVEWKEEGCPTPEQGCRVSY
DPDLYYNPDALPIRLEQPLQMPAPVTTREAHDAETDPLLRMAPGYERYKRISLLYETSLT
DTLRQVGSEDGGDEGRKKFIVHLARKCRQSAIPEEDAVRFALIHPFGREQEMELRATFGN
VYRKEKHCSVRPCMPRRMLVAMQMEEFMTRRYELRFNRMKGCKEYRERHSLFTDYRPVTA
EAVKSICFEAQLEGISAIEYDVQRYVDSRRVSHYWPIEEFLFDLPHWDGQDRIRALADCV
PCENKEWRDFFYIWFLSMVAHWLQMDREHANSTSPLLVGPQGCRKSSFCQSLLPPELRPY
YVDGIDLGSRKDAEMALNRFALINLDEFDSIPASRQPYLKNLLQKAKVTLRKPYGESMEE
MRRFASFIATSNTFSLLTDTTGSRRFIGVEVKGMIRIEPIDYPQLYAQAVSALREGERYW
FTPEEEVLLNRNNRMFEKRPLLEELFLHYFRIPEEEEVCEPLSAPEILMTISKQSKIDLT
ETKLRLFGQLMQKYNVRKKMKKDRKYYYVIPETEEPGADVPVG