Protein Info for HMPREF1078_RS11575 in Parabacteroides merdae CL09T00C40

Annotation: histidine ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 48% identical to HUTH_ALKOO: Histidine ammonia-lyase (hutH) from Alkaliphilus oremlandii (strain OhILAs)

KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 94% identity to pdi:BDI_3648)

MetaCyc: 45% identical to HutH (Bacillus subtilis)
Histidine ammonia-lyase. [EC: 4.3.1.3]

Predicted SEED Role

"Histidine ammonia-lyase (EC 4.3.1.3)" in subsystem Histidine Degradation (EC 4.3.1.3)

MetaCyc Pathways

L-histidine degradation III (6/6 steps found)
L-histidine degradation VI (7/8 steps found)
L-histidine degradation I (3/4 steps found)
L-histidine degradation II (3/5 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (496 amino acids)

>HMPREF1078_RS11575 histidine ammonia-lyase (Parabacteroides merdae CL09T00C40)
MGNVHYVGAEPLTFERIEEILTGNMKLELTPEVKERIQRCRDYLDRKIETQSEPLYGITT
GFGSLCNKNISPDELSTLQENLVKSHACSVGDEVSPVIVRLMMLLKAHALSLGHSGVQVI
TVQRILDFFNNDVLPIVYDRGSLGASGDLAPLANLFLPLIGVGDVYYKGKKREAISVLDE
FAWKPVRLMSKEGLALLNGTQFMSANGVFALMRAFAVSKRADLIAALSLEAFDGRIDPFM
DCIQQMRPHPGQIETGDAFRRILEGSELISRKKEHVQDPYSFRCIPQVHGATKDAIRYVS
GVLLTEINSVTDNPTIFPDEDKIISGGNFHGQPLAISYDFLAIALAELGNISERRVAQLI
MGLRGLPEFLVANPGLNSGFMIPQYAAASMVSQNKMYCYAASSDSIVSSNGQEDHVSMGA
NAATKLFKIMDNLDHILAIELMNAAQGIEFRRPARTSPILEKFLKAYRKEVPFIGEDIIM
YPEIHRTVAFLRRYTL