Protein Info for HMPREF1078_RS11285 in Parabacteroides merdae CL09T00C40

Annotation: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00383: dCMP_cyt_deam_1
  • amino acids 4 to 103 (100 residues), 69.8 bits, E=2.5e-23
• TIGR00326: riboflavin biosynthesis protein RibD
  • amino acids 8 to 320 (313 residues), 292.9 bits, E=1.8e-91
• PF14437: MafB19-deam
  • amino acids 22 to 106 (85 residues), 40.2 bits, E=4.7e-14
• PF01872: RibD_C
  • amino acids 150 to 321 (172 residues), 125.3 bits, E=4.3e-40

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 75% identity to pdi:BDI_3695)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

• flavin biosynthesis I (bacteria and plants) (8/9 steps found)
• flavin biosynthesis III (fungi) (7/9 steps found)
• toxoflavin biosynthesis (3/7 steps found)
• flavin biosynthesis II (archaea) (5/10 steps found)

KEGG Metabolic Maps

• Riboflavin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Protein Sequence (347 amino acids)

>HMPREF1078_RS11285 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD (Parabacteroides merdae CL09T00C40)
MVVEEKYMARCIELARGGEGNTAPNPMVGAVIVHKGKIIGEGFHRKCGEAHAEVNAVASV
RDEALLRDSTIYVSLEPCSHYGKTPPCAELIIRKGIPRVVVGTLDPFPEVSGRGVRMLRE
AGIEVVTGVLEEEARALNPAFMTFQIRKRPYVYLKWAQSADGFIDIRREDASVPSVLLSS
AETLRRVHRLRSEVAAIMVGTRTALLDNPSLTVRHWAGRSPVRVVLDRTLKLPVGSHLLD
GAVPTLVFTAVEVESRPNVEYVQIDFGQEVLSQVLQYLYGQNLNSLMVEGGAELLESFLD
AGLWDEAWVETAPVVLGAGVKAPAVPGVLTGTEQRHGHLLETWKQKA