Protein Info for HMPREF1078_RS10740 in Parabacteroides merdae CL09T00C40

Annotation: chromosomal replication initiator protein DnaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 PF11638: DnaA_N" amino acids 6 to 65 (60 residues), 56.4 bits, see alignment E=5.8e-19 TIGR00362: chromosomal replication initiator protein DnaA" amino acids 9 to 458 (450 residues), 481 bits, see alignment E=2e-148 PF00308: Bac_DnaA" amino acids 127 to 343 (217 residues), 251.7 bits, see alignment E=2.3e-78 PF00004: AAA" amino acids 163 to 247 (85 residues), 24.6 bits, see alignment E=8.9e-09 PF01695: IstB_IS21" amino acids 164 to 265 (102 residues), 29.4 bits, see alignment E=1.7e-10 PF00910: RNA_helicase" amino acids 164 to 238 (75 residues), 24.6 bits, see alignment E=9.2e-09 PF08299: Bac_DnaA_C" amino acids 371 to 439 (69 residues), 96.5 bits, see alignment E=2.3e-31

Best Hits

Predicted SEED Role

"Chromosomal replication initiator protein DnaA" in subsystem DNA-replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (462 amino acids)

>HMPREF1078_RS10740 chromosomal replication initiator protein DnaA (Parabacteroides merdae CL09T00C40)
MQTEYQTLWNKCLAVIKDIVPEAAFNTWFKPIIPLSYEDNKFTIQVPSQFFYEYLEEKYV
NVLKVTLYRVIGQGTILNYRIKVVDKVKEDGMITLPTGNDAPRTGKKSADIPSLFESKAR
QDWDSHLNPKYNFDNYFEGTSNRLVRSSSEAIAQEPGKTFNPMFVFGASGVGKTHLCHAI
GNRIQEIHPEKKVLYISAHLFTVQYTEAIRKNTTNDFMYFYQGVDVLILDDIQELIGKDK
TQNTFFHIFNHLHLLGKQLILTSDKAPVDLQGMEERLITRLKWGLTAELDRPDLDLRKKI
LKNKISHDGVVIPDDVFNFIASNVTENVRDVEGIVASLLAYSTAFNRMIDLPLTKQVVSR
VVKLEKKQVSVESIQDVVCKYYNLELAAIQTNSRKREIVQARQVTMYLAKKYTDSSFSHI
GKIVGKRDHATVLHACKTVRDQIETNKSFRSSVEEIEALLKA