Protein Info for HMPREF1078_RS10540 in Parabacteroides merdae CL09T00C40

Annotation: type I methionyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 41 to 285 (245 residues), 302.8 bits, E=9.1e-95
• PF00557: Peptidase_M24
  • amino acids 48 to 278 (231 residues), 178.2 bits, E=9.5e-57

Best Hits

Swiss-Prot: 53% identical to MAP11_SYNY3: Methionine aminopeptidase A (slr0918) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 89% identity to pdi:BDI_3150)

MetaCyc: 48% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (6/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Protein Sequence (286 amino acids)

>HMPREF1078_RS10540 type I methionyl aminopeptidase (Parabacteroides merdae CL09T00C40)
MHSRRIKNNWHIIKGQPLTELDKKVLYYQNKGHLVPPRKLIKTAEQIEGIRRSSVVNTGV
LDLVAREIKAGMSTAEIDKLVYDYTVSHGAIPAPLNYEGFPKSVCTSVNEVVCHGIPSED
EILEEGDIINVDVSTILDGYYSDASRMFIIGKTTPEKEKLVRVTKECLEIGMQAAKPFGF
VGDIGNAIQRHAEKNGYSVVRDLCGHGVGLEFHEEPEVCHFGRKGTGMLLVPGMVFTIEP
MINMGTWQVFIDEEDGWTVVTEDELPSAQWEHTFLMTETGLEILSY