Protein Info for HMPREF1078_RS09985 in Parabacteroides merdae CL09T00C40

Annotation: substrate-binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 910 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 341 to 361 (21 residues), see Phobius details PF13407: Peripla_BP_4" amino acids 32 to 286 (255 residues), 124 bits, see alignment E=2.9e-39 PF00512: HisKA" amino acids 400 to 465 (66 residues), 48.4 bits, see alignment 2.7e-16 PF02518: HATPase_c" amino acids 513 to 617 (105 residues), 89.6 bits, see alignment E=6.7e-29 PF00072: Response_reg" amino acids 661 to 768 (108 residues), 74.6 bits, see alignment E=2.5e-24 PF12833: HTH_18" amino acids 832 to 908 (77 residues), 75.9 bits, see alignment E=8.7e-25 PF00165: HTH_AraC" amino acids 875 to 907 (33 residues), 35.2 bits, see alignment (E = 3.5e-12)

Best Hits

KEGG orthology group: None (inferred from 62% identity to pdi:BDI_1484)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (910 amino acids)

>HMPREF1078_RS09985 substrate-binding domain-containing protein (Parabacteroides merdae CL09T00C40)
MKPALTYYALLVLLLASCFSCKTDSEKKKFVIGVSQCTLEGSWRKSMLLDMKVQASEYPG
VSLLVEDAADSSLLQVEQIRSLIKRKVDLLIISANESEPVTPIAIEAYRAGIPTILVDRK
ISSDEYTTYIGGNNYEIGRQAGFFVNRQVKEKYPTVLEVWGLSGSSPAQDRHRGFMEVLN
SRIKVKEIFGKWKPETVEKEIAEMDSLEEVDVVFAHNDVMAMAARRAIERMHPGLADRIC
FVGIDAVSGRGSGLEAVMHGELAASVLYPTGGSLAIRVAMQILNGEDVSRQYLLSSALID
KNNAGTLFIQSEQVVDYQHQIELQRENLESMLSKYTFLQNSVGIILLLMGMLLLSALYVV
HVNRAVKRKNRELKRTNLQVQQQKEELAEANRYIEKSTAQKLQFFTNITHEIKTPLTLIL
GPLGKLSKEAPEGSSLADDIRIIRKNAERLKRVVDQLLDFRKVESNKMNMRVGEVDLVAF
VAEVKSYFDTMAATKQIHFTFEHDCPSVNIWVDRDKMEKILANLLSNAFKFTLDGGTVTI
HLKDKGDQVELSVEDNGKGIPSENIASVFDRFFTGDQNYVTGTGIGLHLTREFVHMHKGT
IRVESVPHKSTVFTVILLKGKSHFDESCTFDLSVTELSSGVADLNTDELQEVLNRTYNYT
VLVVEDDLDIQSYLQAELKQNFRVLVADNGVKALEVLMSEEVSMVISDVMMPEMNGFDLC
RKIKSDIVLSHLPVMLLTALSDDKQQMYGAASGADAYIQKPFNIEVVKLRIIKLLEDRVR
LREAYARDASSPAVSVKEEKAGSMDDLFMNRFLKLIEESYADPDFSIEKGSEKLGLSRVH
LYRKVKELAGVTPTDFLRNYRLKKAAALLRRKAGNVNEVAYATGFGSPAYFSKCFKAVYN
ITPTEYLEKE