Protein Info for HMPREF1078_RS09960 in Parabacteroides merdae CL09T00C40

Annotation: S9 family peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 708 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF07676: PD40" amino acids 148 to 175 (28 residues), 11.4 bits, see alignment (E = 9e-05) amino acids 297 to 318 (22 residues), 15.9 bits, see alignment (E = 3.7e-06) PF00756: Esterase" amino acids 459 to 657 (199 residues), 26.8 bits, see alignment E=1.5e-09 PF00561: Abhydrolase_1" amino acids 478 to 611 (134 residues), 26.3 bits, see alignment E=2.1e-09 PF00326: Peptidase_S9" amino acids 495 to 707 (213 residues), 190.5 bits, see alignment E=9.9e-60 PF01738: DLH" amino acids 537 to 685 (149 residues), 23.1 bits, see alignment E=1.8e-08

Best Hits

Swiss-Prot: 59% identical to DPP5_PORG3: Dipeptidyl-peptidase 5 (dpp5) from Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)

KEGG orthology group: None (inferred from 87% identity to pdi:BDI_1481)

Predicted SEED Role

"Prolyl oligopeptidase family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (708 amino acids)

>HMPREF1078_RS09960 S9 family peptidase (Parabacteroides merdae CL09T00C40)
MNKSIGTMVMATSLLFGACSGDGKTCDRATQQKGNTENVIGRSDIKVKDGRMTPEVLWAM
GRIGGMNVSPDGQKVVYTVAYYSVPENRSNREVFVMNADGTDNKQITKTSYSENEAVWIK
GGKKIAFLCNESGSSQLWEMNPDGSDRRQLSEYEGDIEGFAFSPDEKKVLFISQVKTVKS
TADKYPDLDKATGIIVTDLMYKHWDEWVTTAPHPFVADFDGKAISNPVDIMEGEPFESPM
KPFGGIEQLAWNTTSDKIAYTSRKKTGKEYALSTNSDIYVYDLNTKKTANISEGIMGYDT
NPQYSPDGKFIAWQSMERDGYESDQNRLMVMNLETGEKIFASKDFDSNVDGFVWSADAKA
LYFTGVWHGESQVYKIDLTDSNKITPLTSGMYDYAGVALLGEHKLIVQRHSLSMGDEIYS
IDLADNNKIAQLTTENKHIYDQLTIGKVEGRWMKTTDGKQMLTWVIYPPHFDPNKKYPTL
LFCEGGPQSPVSQFWSYRWNMQIMAANDYIVVAPNRRGLPGFGMEWNEQVSGDYGGQCMK
DYFTAIDEMAKESFVDKDRLGCVGASFGGFSVYWLAGHHNKRFKAFIAHDGIFNMEMQYL
ETEEMWFANWDMGGAYWEKQNATAQRTFANSPHLFVDKWDTPILCIHGEKDYRILANQGM
AAFNAAVLRGVPAELLIYPDENHWVLKPQNGVLWQRTFFEWLDMWLKK