Protein Info for HMPREF1078_RS09680 in Parabacteroides merdae CL09T00C40

Annotation: amidohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01979: Amidohydro_1
  • amino acids 46 to 392 (347 residues), 245.5 bits, E=9.4e-77
• PF07969: Amidohydro_3
  • amino acids 184 to 392 (209 residues), 55.2 bits, E=8.9e-19

Best Hits

Swiss-Prot: 49% identical to DADD_METB6: 5'-deoxyadenosine deaminase (dadD) from Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)

KEGG orthology group: K12960, 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC: 3.5.4.- 3.5.4.28] (inferred from 77% identity to pdi:BDI_1084)

Predicted SEED Role

"S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase" (EC 3.5.4.28)

KEGG Metabolic Maps

• Atrazine degradation

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.-

Use Curated BLAST to search for 3.5.4.- or 3.5.4.28

Protein Sequence (419 amino acids)

>HMPREF1078_RS09680 amidohydrolase (Parabacteroides merdae CL09T00C40)
MSILIKGALLDGAVTDVYIEKKEIRQVGTDLQVQADQVIDGRRKALIPGFVNAHTHAAMT
LFRGFGDDMPLMPWLEQKIWPNEAKLTREDVYWGTKLACLEMIKSGTTTFFDMYHKFRAT
ADAVEEMGLRALLAGVCFDHFKPELAEKSKRENEKLVVDVENYSKRIRYAVGPHAIYTVS
GELLQWIHGFAAEHSVPIHLHLAETEGEVRNSIKQFGFTPVRYLYKLGILSPRLIIAHGI
YVDDDEIRMLADHGVKVVHNPASNMKLASGIQFKFCEMRKAGVTVALGTDGCSSSNNLDM
IEAMKLASLLGKAWRKDPEAIPASEIFQAATEAGALAIGLKAGRIAEGYLADLCLVDLDI
PAFTPNHNFVSNLVYAANGSCIDTVICDGKILMQDKKVPGEEEIMEHTAELAYKLVREP