Protein Info for HMPREF1078_RS09220 in Parabacteroides merdae CL09T00C40

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 transmembrane" amino acids 17 to 37 (21 residues), see Phobius details amino acids 273 to 296 (24 residues), see Phobius details PF00512: HisKA" amino acids 331 to 395 (65 residues), 52.7 bits, see alignment E=5.4e-18 PF02518: HATPase_c" amino acids 440 to 548 (109 residues), 86.1 bits, see alignment E=3.4e-28 PF00072: Response_reg" amino acids 572 to 684 (113 residues), 55.4 bits, see alignment E=9.8e-19

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (802 amino acids)

>HMPREF1078_RS09220 hybrid sensor histidine kinase/response regulator (Parabacteroides merdae CL09T00C40)
MNNNTFSRWKESLHLKILSGYLILGLLVLGIITAVWYEKQVFEQAEAEERSLLMQRAAAS
EAYRGLITLFLDNDRVMLWDDSDMDTYDRRESHTMEVIDRLKGYYGEPAQTARIDTVVRL
LHEKRRLIERMVDMPTTAYRMDSLLERHLPGLEQTASVRTTTVTERTEPEEEKKRGGLFG
LFRKKKKEEPARTTTRVSTTPNTRHIAEMRRFEEEMRTALAEQEQAFSHLSDSLKIRNSI
LNRNLSRLIREIGQDETERMEERHMRVAELRETAFVLICGISAAGVLCAVLLYAVVRRDI
HRRTRDRKQREELIETLRQSVRENEELIKSRQNIMQTVTHDLRSPLTAIRGNAELILKDG
NREATALHAEHIRQSAERMGALMENLLDYYRIDNGKETVRVKPFRLAGVAETLETEFAAR
MEEKRLEFRVNNAADEVVMGDRNLILRIGSNLLSNALKFTERGGVTLTALYAGGKFTLAV
EDTGGGIDKDKREQIFKPFERLSNAATQDGFGLGLSIVKSLAELMEGSISVENIRNTGSR
FSVVLPLPQAEKAGETGRKAAAKRTRLGGCSVLSLDNDSIILGMIHDIFVQNGVHCDTCT
STGEMAEKLREGHYDLLTTDLKMQDASGYEVLELLRTSDIGNSRTIPVMVVTGSKSITKE
ELAGAGFGSVLYKPFSIDELLAAAEECIGEDSTPRIDLGPLFAYGDKRQRLECLVRETEK
EMAAIREEAERCDRDRLDYWIHHIRSSWMLIHAEGPLQELYDVLHGNGTAEEIREYAGKV
TGQGETIIRLARKEMERTVWEE