Protein Info for HMPREF1078_RS08705 in Parabacteroides merdae CL09T00C40

Annotation: aldose epimerase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 359 PF01263: Aldose_epim" amino acids 29 to 355 (327 residues), 295.7 bits, see alignment E=2.2e-92

Best Hits

Swiss-Prot: 49% identical to GALM_BOVIN: Aldose 1-epimerase (GALM) from Bos taurus

KEGG orthology group: K01785, aldose 1-epimerase [EC: 5.1.3.3] (inferred from 84% identity to pdi:BDI_1664)

MetaCyc: 48% identical to aldose 1-epimerase (Homo sapiens)
Aldose 1-epimerase. [EC: 5.1.3.3]; 5.1.3.3 [EC: 5.1.3.3]

Predicted SEED Role

"Aldose 1-epimerase (EC 5.1.3.3)" in subsystem Lactose and Galactose Uptake and Utilization or Maltose and Maltodextrin Utilization (EC 5.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.3

Use Curated BLAST to search for 5.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (359 amino acids)

>HMPREF1078_RS08705 aldose epimerase family protein (Parabacteroides merdae CL09T00C40)
MKNESTLSGLTVANFSKQIDGKETMLCILTNNKGAELTITNYGAKIVSLMVPDRSGKLTD
VVTGHNSIDEYLVSEEPYFGAICGRYGNRIASGKFTLDGIVYDKLAINNGPNSLHGGLKG
FNSVVWDLNKIDGQTVELKYTSADGEEGFPGKLDTTVTYHLSDDNEVIITYHAVTNKPTV
LNLTNHSYFNLSGQGDPSVYDHKLTINADYYLPTDETAIPYGPKEKVEGTPMDFRTPHEV
GERIDEDFEALNFGKGYDHTYILNKKEENELSLCARCTSPKTGIVMECYTTQPGVQLYTG
NWMTGNFVGKNGQRYPARAALCLETQHYPDSPNKPEYPSTVLRPGETFQSKTIYKFSVE