Protein Info for HMPREF1078_RS08660 in Parabacteroides merdae CL09T00C40
Annotation: glycosyltransferase family 2 protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 38% identical to GTRB_ECOLI: Prophage bactoprenol glucosyl transferase homolog (yfdH) from Escherichia coli (strain K12)
KEGG orthology group: K00721, dolichol-phosphate mannosyltransferase [EC: 2.4.1.83] (inferred from 86% identity to pdi:BDI_1651)MetaCyc: 38% identical to CPS-53 (KpLE1) prophage; bactoprenol glucosyl transferase (Escherichia coli K-12 substr. MG1655)
Phosphopolyprenol glucosyltransferase. [EC: 2.4.1.78]
Predicted SEED Role
"Glycosyltransferase"
MetaCyc Pathways
- protein O-mannosylation II (mammals, core M1 and core M2) (1/5 steps found)
- protein O-mannosylation III (mammals, core M3) (1/5 steps found)
- protein O-mannosylation I (yeast) (1/8 steps found)
- protein N-glycosylation (Haloferax volcanii) (1/11 steps found)
- protein N-glycosylation initial phase (eukaryotic) (1/19 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.4.1.83
Use Curated BLAST to search for 2.4.1.78 or 2.4.1.83
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (310 amino acids)
>HMPREF1078_RS08660 glycosyltransferase family 2 protein (Parabacteroides merdae CL09T00C40) MKKLAVIVPCYNEELVIAESYRRTREALHKLPVLTEIIYINDGSRDRTRLMLDEIAASDP QVKVIHFSRNFGHQPAVTAGINNCDADLAVILDADMQDPPELIPSILELQEKEQANVVYC VRKSREGEGLFKKVTAKAFYRMLNYMSDVNFPLDTGDFRLIDRKVMDQFDRFQERGKYIR GLISWVGFKQVPFYYEREARIAGETKYPFSKMWKFATTAMLYFSKKPLRLATSLGFIAVL VGIVLAVWFTLGKIYGFSNAETGWTSIMTSVIFFGGVQLLTVGVLGQYIGILFDEIKARP EYIIDEKKNF