Protein Info for HMPREF1078_RS08375 in Parabacteroides merdae CL09T00C40

Annotation: two-component regulator propeller domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1377 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 785 to 806 (22 residues), see Phobius details PF07494: Reg_prop" amino acids 80 to 103 (24 residues), 25 bits, see alignment (E = 5e-09) amino acids 218 to 240 (23 residues), 24.8 bits, see alignment (E = 6.1e-09) amino acids 538 to 558 (21 residues), 17.5 bits, see alignment (E = 1.4e-06) amino acids 579 to 602 (24 residues), 16.1 bits, see alignment (E = 4.2e-06) PF07495: Y_Y_Y" amino acids 714 to 777 (64 residues), 75.1 bits, see alignment 1.4e-24 PF00512: HisKA" amino acids 833 to 898 (66 residues), 35.2 bits, see alignment 4.1e-12 PF02518: HATPase_c" amino acids 945 to 1075 (131 residues), 78.6 bits, see alignment E=2e-25 PF00072: Response_reg" amino acids 1125 to 1234 (110 residues), 85.3 bits, see alignment E=1.3e-27 PF12833: HTH_18" amino acids 1290 to 1368 (79 residues), 69.8 bits, see alignment 7.8e-23 PF00165: HTH_AraC" amino acids 1331 to 1368 (38 residues), 28.4 bits, see alignment (E = 5.5e-10)

Best Hits

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1377 amino acids)

>HMPREF1078_RS08375 two-component regulator propeller domain-containing protein (Parabacteroides merdae CL09T00C40)
MRKTYLITLLLCCFSALLNGAVSPFSFSSLKMEEGLSQLSVLKIHQDKSGFMWFATRNGL
NRYDGNSFVVYKHSNGDSLSLSSNHVTALAEDDRGNLWVGTMNGLNRMDLRVDRVYSLND
MAAYKQSPLYHTWISSLYVDRQKRFWVGTNKGLYLYDYENDSFILNDLEGELPRDQIMVI
NEDHDGNLLVGTLQNGLYICDSKLNLLSHYFKNTTPFSLTDNNISAIHEDSEGRLWVGTR
SGGLNRIDTETNAVTHYTAWNGRLGNNSVRTINTYNGQLVVGTFNGLSLLNLVDGSCTTY
TNFDEQKGGLSHFSVFSAFVDNANTLWIGTYAGGVSYSNPLNSRFTFYDLQGGSDKLFGI
FATMAYQPDHTLWIASEGRGLLSLDLNTDMFERFLLDARPNALNDRNIIKSLFVEGDFVW
CGTQKGTLYRFDTRTKKFSLFYTFHKEVSIYTITRCSDGALWLGTTDNTGIVRVFPDGRI
APSDSVFALLPSVRSFLEIRDGVYLVGMHTGGLALYDSHTHKLIKYNTREEGSRKLYNDQ
VSNIVKDREGRIWIGTFGGGFCRFDEEKGIMEWLTAVEGLSDDNINSIIPGDDGKLWIST
GNGISAYDPESRQFTNYMGRSEIPVNEFSMKGGIKLPGDRIYFSGSNGLVSFYPERLIEN
RFIPPVVLTSFTVNNKPVVPGDPSGLLDKVLDYTQAIDLDYNQNNFSVGYAALNYLYPNQ
NKYAYMLEGYDTDWNDAGSRKEAFYTNLKPGDYVFRVRASNNDGLWNDEGRSLSIHIRTP
FWQTWYAYMLYLLIIGGIFYVVWYYLHMKRKLEQDLVEKQKEQQRQEEFHQSKIRMFTNF
SHELRTPLMLILSPLEEVLQRVDMNPNLKGSLRLVYGNAQRLLLLVNQLMDLRKNQSGNL
QLRVSHNDLYLFTQEIYIAFNQIAVKERIIFRLESDESGIDAWFDRVLLEKVFFNLLSNA
FKHTAPDESITIRLQLFSVAGLQEQFPGRISGEVRGTSRYVCLSVEDTGKGIDDSDKFHI
FSPFYQGTDESESNTAGTGIGLSLVLSIVKLHKGVVWVEDNKPKGAVFRVLIPVNREVYA
HEQFAEDDSSARNPYGGIEVAEDESKVPDNMQEQLPVSGQRYTLLLAEDNPDVRRYICKH
LEPYFDVLEAENGVDAFNKIAETLPDLVVSDIMMPKKDGLQLCSEIKQDLRTGHIPVIII
TAKSMVMHIKEGFQCGADDYIVKPFNMEVLLCRIRNILASRERLKELYGKKFSLESLGFE
TTSADDTFMQKLFGVIEQNLSNPGLNVEILCKGVGMGRANFYRKLKAITDLSPVDLIRNK
RLEIAARMLLETDMNISEVSANIGFNSHAYFATCFKAMYGMSPTEYVQQNKKNLYHV