Protein Info for HMPREF1078_RS08145 in Parabacteroides merdae CL09T00C40

Annotation: TonB-dependent receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1026 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 43 to 1026 (984 residues), 993.3 bits, see alignment E=1.7e-302 PF13620: CarboxypepD_reg" amino acids 43 to 104 (62 residues), 43.6 bits, see alignment 6.4e-15 PF13715: CarbopepD_reg_2" amino acids 43 to 123 (81 residues), 75.1 bits, see alignment E=7.6e-25 PF07715: Plug" amino acids 131 to 237 (107 residues), 64.9 bits, see alignment E=1.8e-21 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 213 to 243 (31 residues), 62.1 bits, see alignment (E = 3.2e-21) PF00593: TonB_dep_Rec_b-barrel" amino acids 447 to 983 (537 residues), 61.9 bits, see alignment E=2.2e-20

Best Hits

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1026 amino acids)

>HMPREF1078_RS08145 TonB-dependent receptor (Parabacteroides merdae CL09T00C40)
MNYTYMKGCALCMTLCLTSAALPGRANAESSAIVNEVLQSSVVKGVVKDSNGEPLLGVNV
LVKGTTIGAVTDIDGNFSFEAPAGCTLVISYIGFESQEVKVKGNAPLNIILKEDSEALDE
VVVVGYGVQKKSDVTGALSSVKGDDLTKLSISRTDQALQGQMAGVMVQNSVAAPGESPNI
IIRGGNSLKGENAPLVVIDGVLGGDLSLIDPNDITSIEVLKDASSTSIYGSRGANGVIMV
TTKRGQTGKPTVSYSGYVSLSQVSKKMDMLNGQELYGLLKEAQEKYPTTALKIPEWIDPN
NLNNTDWQGEVFRTAPITGHSLSVSGGTETTRYSLSGNYLMHQGIVKNSDFNRAGIRANI
EQKLGKKVTVGALINASRSSSSNASVNQMNGSDGGGVTFSALGFGPLVPVYKEDGSLSGP
LKDGAQMNNPVALINDQVVDKFRNYFQGTAFLEWEILNGLKFKTAWTYTYSDRKQRQFTS
GENLLSYKGQGYAYMNDQETTNWLGENTLTYSKTFNKDHSLNVVAGFTAEASDYFNNNSS
GKGFDIESLGYWNMGLANSSLLSVASGGNHSAIASWLGRVNYAYKGKYLASVSFRADGSS
KFAKNNKWGYFPSAALGWRISEEDFMKDISWIQNLKLRASYGETGSQAITAYQSLASFST
TSYVLNGSSAVALVPGRVPNPDLKWETTKQTDIGIDLSVLGGRISLVADYYYKKTVDLHY
DKILPYYTGYSSQTQNIGSKSNKGWEFSLNTQNLVGDFKWSTSLNIALNREKVLDLGDDE
YFYTNGSGGALGAGFNETGIVKVGEPLGNFYGYVFDGIYQNEAEAKALGLTKDDVGSVKF
KDLNGDNKITTEDRTIIGNANPDFIFGIGNDFSYKNFDLSFMFQGTYGNDVYNLLKVTFS
ELPSNSNNTGNAFAFVKDSWRGEGTSNTQQAFNKGVGPSSSRFVEDGSYIRLKNLTFGYT
LPKSVTSKWGISNLRFYLSGQNLFTITGYSGYDPEVSSRTGNYNLGFDGGSYPATRSYTF
GLNLTL