Protein Info for HMPREF1078_RS07525 in Parabacteroides merdae CL09T00C40

Annotation: aspartate-alanine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 566 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 34 to 54 (21 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 92 to 113 (22 residues), see Phobius details amino acids 159 to 177 (19 residues), see Phobius details amino acids 391 to 410 (20 residues), see Phobius details amino acids 416 to 434 (19 residues), see Phobius details amino acids 455 to 473 (19 residues), see Phobius details amino acids 480 to 502 (23 residues), see Phobius details amino acids 542 to 565 (24 residues), see Phobius details TIGR03802: aspartate-alanine antiporter" amino acids 2 to 565 (564 residues), 703.3 bits, see alignment E=2.4e-215 PF06826: Asp-Al_Ex" amino acids 15 to 176 (162 residues), 135.2 bits, see alignment E=1e-43 amino acids 394 to 562 (169 residues), 160.8 bits, see alignment E=1.4e-51 TIGR01625: AspT/YidE/YbjL antiporter duplication domain" amino acids 399 to 548 (150 residues), 98 bits, see alignment E=4.6e-32

Best Hits

Swiss-Prot: 74% identical to Y736_BACTN: Uncharacterized transporter BT_0736 (BT_0736) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K07085, putative transport protein (inferred from 82% identity to pdi:BDI_1071)

Predicted SEED Role

"putative transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (566 amino acids)

>HMPREF1078_RS07525 aspartate-alanine antiporter (Parabacteroides merdae CL09T00C40)
MEWFANLLRHYPELAIFLTLAFGFWIGKFKIKKFTLGTVTSVLLVGVLIGQLHIDIGAPL
KSVFFLMFLFAVGYSVGPQFFRGLKKEGLPQVLFAVVMCLFCLLAPFVLAKIMGYSAGEA
AGLLAGSQTISAVLGVAEDTINQLGIPVADKTDMINVMPVAYAVSYIFGTAGSAWIMSDI
APRLLGGIESVKKACRELEAKMGSDDESEQPGFMPAARPITFRAYKINNGWFGAGKTVKE
LEDYLEGQGRRLFVERVRIDGVIRDAKSDQMLLKGNEVVLSGRREFVIGEEDWIGDEVND
IELLDFPAETLPVLISRKEYAGMTVAKLRKLPVMHGVSIKSIKRAGINIPVLAATTIDPG
DMLELVGTKLEVNAAADTLGYADRPTNQTDMIFVGLGIFLGGVVGALAIHFGGVPISLST
SGGALIAGLVFGWLRSKHPTFGRIPEPSLWVLNNVGLNMFIAVVGITAGPSFVTGLKEVG
VSLFFIGALATAIPLIVGVLLGRYVFKFHPAITLGCTSGARTTTAALGAVEDAVESQTPA
LGYTVTYAVGNTLLIIWGVVIVLLMT