Protein Info for HMPREF1078_RS07480 in Parabacteroides merdae CL09T00C40

Annotation: precorrin-2 C(20)-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00590: TP_methylase
  • amino acids 5 to 212 (208 residues), 107 bits, E=6.4e-35

Best Hits

KEGG orthology group: K03394, precorrin-2/cobalt-factor-2 C20-methyltransferase [EC: 2.1.1.130 2.1.1.151] (inferred from 63% identity to pdi:BDI_1016)

Predicted SEED Role

"Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.1.1.130)

MetaCyc Pathways

• cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (10/15 steps found)
• cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (7/13 steps found)
• adenosylcobalamin biosynthesis II (aerobic) (20/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.130 or 2.1.1.151

Protein Sequence (232 amino acids)

>HMPREF1078_RS07480 precorrin-2 C(20)-methyltransferase (Parabacteroides merdae CL09T00C40)
MSYPICFVSLGPGDPELITLKGLKKLRQADIIYCPATISKSGQLLSRAARIIEELEIEKS
VVQFFTLPMSKDRTEVWKVYDTLYEKAISARDKEKKVVIVAEGDAGFYSSIQYIYDKFKE
NRIEVERTAGIPAFIAAGALAGLHIVKQEEQIIVIPGMLTAEELSKKIKTGNVIVIMKLS
QCVEAVHTCIRLHPETNFHYFENVGTGEEFYTSDRKQIQRKIFPYFSLMIIQ