Protein Info for HMPREF1078_RS07450 in Parabacteroides merdae CL09T00C40
Annotation: cobalt-precorrin-5B (C(1))-methyltransferase CbiD
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"Cobalt-precorrin-6x reductase (EC 1.3.1.54) / Cobalt-precorrin-6 synthase, anaerobic" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 1.3.1.54)
MetaCyc Pathways
- cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (10/15 steps found)
- cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (7/13 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (20/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.3.1.54
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (614 amino acids)
>HMPREF1078_RS07450 cobalt-precorrin-5B (C(1))-methyltransferase CbiD (Parabacteroides merdae CL09T00C40) MILILGGTTEGRKAVQVVESAGKPYYYSTVGNEQAIEAVHAIRLTGGMDEEKMAQFCREK KISLLVDAAHPFAIRLHRTLAKVSSRLRIPVVRLERQYPAHDKRLIWCTDYAAAIDRLRA DGICNLLALTGVKTIAKLRPYWEQTPCWFRILNRKESLSLAESDGFPKERIIFFHEGEDE KKLLDQLHPDAVLTKESGESGYFKEKVEAAQACGIPVYVIQRPPLPDSFTFVQGMEGLRK AIERLAPGFFPLRSGFTTGTCATAAAKAALVALLNRTEQTVSCITLPSGEKIMLPVAATE WADNAALCTVIKDSGDDPDVTNGCSVIARIELQAGQSPTPAFLFRAGEGVGTVTLPGLGL EIGGPAINATPRRLITGELTTILEENGLSGKIKEVVVTISVPGGKELAARTFNPKLGIIG GISIIGTSGIVRPFSNDAFLASIRKEAEVAKAIGCSRLVINSGAKSERFLKGYLSERLSE ELPPQMFVHYGNFIGKTLKIAAELQFDEVVMGIMIGKAVKLAEGALDTHSKKVVMNKAFL KELAAKAGCKPESVQKIDSLTLARELWELFSKTEQQSFFPLLLQKCREHCTPLLPNGKLS VLLISESGKITFQA