Protein Info for HMPREF1078_RS07215 in Parabacteroides merdae CL09T00C40
Annotation: 2-oxoacid:acceptor oxidoreductase subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00174, 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC: 1.2.7.3] (inferred from 94% identity to pdi:BDI_2807)Predicted SEED Role
"2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)" (EC 1.2.7.3)
MetaCyc Pathways
- TCA cycle V (2-oxoglutarate synthase) (7/9 steps found)
- reductive TCA cycle I (8/11 steps found)
- incomplete reductive TCA cycle (5/7 steps found)
- TCA cycle VI (Helicobacter) (6/9 steps found)
- TCA cycle VII (acetate-producers) (6/9 steps found)
- reductive TCA cycle II (6/12 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (19/56 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.7.3
Use Curated BLAST to search for 1.2.7.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (618 amino acids)
>HMPREF1078_RS07215 2-oxoacid:acceptor oxidoreductase subunit alpha (Parabacteroides merdae CL09T00C40) MAEQTKVTTLEKVVIRFSGDSGDGMQLTGTIFSNLSAIFGNEISTFPDYPAEVRAPQGTL SGVSGFQVHLGSRKIFTPGDKADVLVAMNPAALKVNVKNLKPNAIVLIDTDSFQKSDLDK AQFTTDDPFQELGLGGVQVVAAPISTMVKDGLAEFGLDNKSALRCKNMFALGLVCWLFER PLDEAMHMLQNKFAKKPAIAQANIKALTDGYNYGHNIHASVSTYRIESKKAAPGFYTDVN GNKATSYGLIAAAEKAGLRLFLGSYPITPATDILHELSKHKELGVITVQAEDEIAGICTS IGASFAGCLAATSTSGPGLALKSEAIGLAVIAELPLVVIDVQRGGPSTGMPTKSEQTDLM QALYGRNGESPAVVIAASTPTDCFDAAYWAGKLALEHMTPVILLTDAFIANGSSAWKLPN LAEYPEIKPNYVSNYDASEKVWKAYRRDKESLVRYWAIPGTEGFAHRLGGLEKDYETSAI STDPVNHQKMVTTRQAKIDKIADYIPELEVIGDPDADLLIVGWGGTYGHLYEAMETMQEQ GKKVALAHFKFISPLPKNTAEVLSKYKKVVVAEQNNGQFANYLRGKVTGFNPYRFNRVKG QPFVVARLVEEFTKILEA