Protein Info for HMPREF1078_RS07145 in Parabacteroides merdae CL09T00C40

Annotation: discoidin domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1208 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF00754: F5_F8_type_C" amino acids 275 to 365 (91 residues), 40.5 bits, see alignment 8.7e-14 PF02837: Glyco_hydro_2_N" amino acids 461 to 544 (84 residues), 46.5 bits, see alignment 1.2e-15 PF00703: Glyco_hydro_2" amino acids 606 to 705 (100 residues), 55.7 bits, see alignment E=2.4e-18 PF18368: Ig_GlcNase" amino acids 1098 to 1207 (110 residues), 88.9 bits, see alignment E=6.8e-29 PF17753: Ig_mannosidase" amino acids 1139 to 1193 (55 residues), 23.6 bits, see alignment 1e-08

Best Hits

KEGG orthology group: None (inferred from 74% identity to pdi:BDI_3021)

Predicted SEED Role

"Beta-mannosidase (EC 3.2.1.25)" in subsystem Mannose Metabolism (EC 3.2.1.25)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.25

Use Curated BLAST to search for 3.2.1.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1208 amino acids)

>HMPREF1078_RS07145 discoidin domain-containing protein (Parabacteroides merdae CL09T00C40)
MKTLDKQKKNVLTLCGAAMASLLLWGCGGTNPTAESFERSDYYTRGIGQYPGDPKEDFSP
SLAPDPSTYRNIARLRSAFASSSHDYNLVAQLATDGIVTDEQPQYLNLSTPDGDVPRRER
EWMIDEGPYSRNTFPGEDTYFRFTLANYSKAAGKLSLVGTVVYDDKVSKGGYEIICQGSN
DGKNWTEIGKLSGSGLPGQAVSGRVVVTDPNKQTGETTMPVRKLNETITFNSENAYSDYR
VLLKMAGAHDWVFTEANFMDKDGGLVEMKPSQFFNSAWMSATGGEEWLYVDLGSMSEFDK
VVLHWINKAVKGKVQVSDDAKLWKDAAELPGGDGLIDEIALNGKQNARYVRVLMQQPAND
SRYILSEVEVMGKGGLVAQPVAPPPASKGKIILSGGNWELQRASEVTASGEEISTLGYKP
ENWIVATVPGTVLSSYKNIGAIADPNYADNQLQVSESFFWSNFWYRDEFEVPEGFKQDRL
FLNFDGINWKANVFLNGKKLGRIEGAFMRGKFDVTDLVVPGKNVVAVEIIRNNHIGAIKE
KNKQSTDFNGGILGADNPTFHATIGWDWIPTVRGRNIGIWNDVFLTSTGKVTVADPLVTS
VLPLPDTTSATLTAEVIVKNHDANTVNGTLEGKVGDITFQQPVSLAAGEEKTVVFDVKDF
PQLKMENPRLWWPKGYGAPNLYDANFTFKVDDKVSDAKDFKVGIRQMTFNEDNHILSLFI
NGRRFIGRGGNWGFGESNLNYRGREYDIAVAYHADMNFTMMRNWVGMIGDEELYEACDRH
GIMIWQDFWLANPADGPDPYYPEMFIANAEDYVKRIRSHASIGLYCGRNEGFPPEQIDKA
LRRIIKEDHPDIHYISSSADDVVSGHGPYRMLPAKEYFTLKTGNDKFHSERGMPNVMTYE
SMLRTFSPEGIWPQDNEWGMHDYTREGAQGCTSFNEIIAKGYGEPQSAKEFACLAQWVNY
DGHRSLFESRSQNRKGLLMWMSHSCWPSMVWQTYDYYFEPTAAYFAIKKASEPLHIQWNP
ATDEVEVVNYSAGTHKGLTAKVQVLNMDASVAWEKEATVDSNEDTTDKCIKLEFPENLSK
VHFIKMTLTEDGKVVSDNFYHRSLEENNYQDLCQLAKVALQSATTVDKNADGTWSAVSVI
ENKTSTPALMIRLNVVGGKDDQQILPVFYSDNYFSLLPGEKKEVRMSWRDEDTRGNEGKV
LITGYNVE