Protein Info for HMPREF1078_RS06310 in Parabacteroides merdae CL09T00C40

Annotation: excinuclease ABC subunit UvrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 601 TIGR00194: excinuclease ABC subunit C" amino acids 11 to 582 (572 residues), 543.1 bits, see alignment E=4.4e-167 PF01541: GIY-YIG" amino acids 19 to 94 (76 residues), 47.8 bits, see alignment E=1.5e-16 PF08459: UvrC_RNaseH_dom" amino acids 382 to 536 (155 residues), 185.3 bits, see alignment E=7.3e-59

Best Hits

Swiss-Prot: 73% identical to UVRC_BACTN: UvrABC system protein C (uvrC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K03703, excinuclease ABC subunit C (inferred from 89% identity to pdi:BDI_2967)

Predicted SEED Role

"Excinuclease ABC subunit C" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (601 amino acids)

>HMPREF1078_RS06310 excinuclease ABC subunit UvrC (Parabacteroides merdae CL09T00C40)
MSTTEEHIKNILSVIPESPGCYQYFDEKGTIIYVGKAKNLKRRVSSYFNKEHDSNKTRVL
VKQIRDIKYFVVDTEEDALLLENNLIKQYRPRYNVLLKDDKTYPSIVVKNEYFPRVFQTR
NIVRDGSRYYGPYPSIYTAKVMLQMLKELYPLRTCKYPLTPESIAKGRYKVCLEYHIKHC
KGPCEGLQTLEEYQQNISEIKEILRGNISQISKHLYEEMQKLAGELRFEEAQKIKEKYEV
IENYRSKSTVVTPMLHNIDVFSLAENENSAYINYLHIGNGAIVQAYTFEYKKRLDESKEE
LLSLGIIEMRNRFKSTAREIIVPFPLDIELENVSITVPQRGDKKKLVELSEMNVKQYKVD
KLKQAEKLNPEQRSTRLLKEIQETLHLPKLPAHIECFDNSNIQGSDAVAACVVFKMAKPS
KKDYRKYNIKTVVGPDDYASMKEVVRRRYQRAIVEETPLPDLIITDGGKGQMEVVREVIQ
DELHLDIPIAGLAKDGKHRTSELLFGFPPETIGMPIQSFMFKFFTQIQDEVHRFAITFHK
DKRSKSQTKSELDTIKGIGEKTKVLLLRHFKSVKRIREAGFDELKEVIGEAKTKALLNGL
K