Protein Info for HMPREF1078_RS06110 in Parabacteroides merdae CL09T00C40

Annotation: beta-galactosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 780 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF01301: Glyco_hydro_35" amino acids 39 to 353 (315 residues), 412.1 bits, see alignment E=6.3e-127 PF02449: Glyco_hydro_42" amino acids 59 to 202 (144 residues), 25.9 bits, see alignment E=1.9e-09 PF21317: BetaGal_ABD_1" amino acids 400 to 511 (112 residues), 81.9 bits, see alignment E=9.8e-27 PF21467: BetaGal_gal-bd" amino acids 532 to 590 (59 residues), 88.6 bits, see alignment 7.2e-29 PF00754: F5_F8_type_C" amino acids 706 to 774 (69 residues), 35 bits, see alignment E=4.2e-12

Best Hits

KEGG orthology group: K12308, beta-galactosidase [EC: 3.2.1.23] (inferred from 72% identity to bfs:BF3667)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (780 amino acids)

>HMPREF1078_RS06110 beta-galactosidase (Parabacteroides merdae CL09T00C40)
MKHVNKILAGLITCCVILLLSGCSPRQGEKHDFSIGKGTFLLDGKPFVIKAAEIHYTRIP
AEYWQHRIQMCKALGMNTICIYAFWNIHEQKPGEFDFKGQNDIAAFCRLAQKEGMYIMLR
PGPYVCSEWEMGGLPWWLLKKEDIKLRTNDPYFLERTKLFMNEIGKQLADLQVTRGGNII
MVQVENEYGAYATDKAYIANIRDAVKAAGFTDVPLFQCDWSSTFQLNGLDDLVWTINFGT
GANIDAQFKKLKEARPDAPLMCSEFWSGWFDHWGRKHETRDAGVMVSGIKDMLDRHISFS
LYMAHGGTTFGHWGGANSPAYSAMCSSYDYDAPISEAGWATPKYYKLRELLTQYADSGQV
IPDVPAAYPLIEIPAFTVGEVAPLFDNLPAPQASKEIKPMEQFDQGWGTILYRTTLPAVK
EGTTLLIDEVHDWAQVFADGKLLGRLDRRRGENTVVLPALAAGTRLDILVEAMGRVNFDV
AIHDRKGITDKVELISDTGRQELEDWQVYSFPVDYAFVQDKKYAAGDKLDGPAYYRTTFE
LDEVGDVFLDMQTWGKGMVWVNGKAMGRFWEIGPQQTLFMPGCWLKKGKNEIIILDLLGP
EKAVVEGRKEPILDMLRAEAPATHREEGQTLNLKGEKPVANGALKPGNGWQEVKFGQTVK
GRYFCLEALDAQDGKDNAAMAEFYLLDEDGKPLPRQHWNISYADSESTQWGNFTADKIYD
LQESTYWSTKRGDKYPHQVVIDLKEEQTISGFRYLPRAEEGFPGMIKGYKAYVKATPFAM