Protein Info for HMPREF1078_RS05700 in Parabacteroides merdae CL09T00C40

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 transmembrane" amino acids 24 to 42 (19 residues), see Phobius details amino acids 52 to 73 (22 residues), see Phobius details amino acids 89 to 111 (23 residues), see Phobius details amino acids 254 to 276 (23 residues), see Phobius details amino acids 289 to 312 (24 residues), see Phobius details amino acids 595 to 614 (20 residues), see Phobius details amino acids 620 to 639 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 86 to 637 (552 residues), 537.8 bits, see alignment E=5.6e-165 TIGR01512: cadmium-translocating P-type ATPase" amino acids 86 to 639 (554 residues), 465.9 bits, see alignment E=2.4e-143 TIGR01494: HAD ATPase, P-type, family IC" amino acids 108 to 615 (508 residues), 233.4 bits, see alignment E=5.9e-73 PF00122: E1-E2_ATPase" amino acids 136 to 320 (185 residues), 147.7 bits, see alignment E=4.2e-47 PF00702: Hydrolase" amino acids 337 to 546 (210 residues), 98.9 bits, see alignment E=7.9e-32 PF08282: Hydrolase_3" amino acids 524 to 582 (59 residues), 21.1 bits, see alignment 3.6e-08

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 73% identity to pdi:BDI_0217)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (644 amino acids)

>HMPREF1078_RS05700 heavy metal translocating P-type ATPase (Parabacteroides merdae CL09T00C40)
MEAKTTCHSGCSCGHNKGEEHPNVVLPILSFILLIVGLILDHTGQGWFSPTVKLVWYLAA
FLPVGLPVIREAYHEALRKDFFTEFTLMSVASTGAFSIGEYPEAVAVMLFYTVGEMLQNR
AVERASQNISRLLDVRPERTDVFREGNYINVSPKEVRTGERIEVKPGGRIPLDGILQETE
ASFDTSALTGESMPRILRKGDEVLAGMIVLGQTVRIEVNRPYEQSALARILVLVKDAAER
KAPAELFIRRFARFYTPAVIVLALLIVTVPAFAGLMMPSFQYVFHDWLYRGLVFLVISCP
CALVISVPLGYFGGIGAASRAGILFKGGNYLDAITQINTIAFDKTGTLTTGCFDVTDMQA
HRISESELLTLLLSVEQKSTHPIAQAIVRYAKKQNISAASVSEMHELAGHGVEAVIGGQE
VLVGNIRLMKERGISIPEELSDQVATVVICAIDKKYAGHLLLSDTLKDDAVEAIAKLRKL
GVTDIRLLSGDKKEIVASFARRLGIDRAYGNLLPEDKAAHIREMVEEPGKTVAFVGDGMN
DAPVLALSHVGIAMGGLGSDAAIESADVVIQNDQPSKVATAITIGRKTRTIVHQNIIGAL
VVKGIVLSAGALGYATLWGAVFADVGVALLAVLNSVRILNRKVW