Protein Info for HMPREF1078_RS05600 in Parabacteroides merdae CL09T00C40

Annotation: sulfatase-like hydrolase/transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 480 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00884: Sulfatase" amino acids 25 to 373 (349 residues), 174.2 bits, see alignment E=6.2e-55 PF01663: Phosphodiest" amino acids 28 to 322 (295 residues), 27.6 bits, see alignment E=3.5e-10 PF16347: SGSH_C" amino acids 324 to 466 (143 residues), 78.2 bits, see alignment E=1.2e-25

Best Hits

Predicted SEED Role

"Choline-sulfatase (EC 3.1.6.6)" in subsystem Choline Transport or Choline and Betaine Uptake and Betaine Biosynthesis (EC 3.1.6.6)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.6

Use Curated BLAST to search for 3.1.6.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (480 amino acids)

>HMPREF1078_RS05600 sulfatase-like hydrolase/transferase (Parabacteroides merdae CL09T00C40)
MKQALSLIGVSFLSVVSSLAADKKPNIILILADDMRASGMNFLGKEQVQTPNLDKLAGES
TVFTNAHIMGGTSGAVSMPSRAMLMTGKYLYNLEKQGATIPNSHTMIGETLQKAGYNTFH
TGKWHSSYEALNRCFKEGKAIFFGGMWDHWNVPLYDYHADMNYGKRRPVIHNQAKSNKVE
YEIGEYMYSGKHSVDIFTHEAVEYIQQQKDKNQPFFLSVAYMSPHDPRSMPDEYMQLYDQ
SQIQLPPNFMEKHPFDNGELEIRDEILAAIPRRPDEIKKHIREYYAMISHVDKRVGNIIQ
TLKDNGLYENTIIIFAGDNGLAVGQHGLMGKQNVYEHSVGVPLMIKAAAQHTGKKTADLC
YLIDVFPTLCDMLQLPVPQSVDGISLLSSLDGKEPVRDYLYYSYMDNQRGISDGTWKLIE
YHVNGKRTTQLFNLKNDPWERNDLSGQKKYEKTIQRLREKMAEEQKRTNDTSVFWNNFSY