Protein Info for HMPREF1078_RS05290 in Parabacteroides merdae CL09T00C40

Annotation: signal peptide peptidase SppA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 591 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details TIGR00705: signal peptide peptidase SppA, 67K type" amino acids 22 to 561 (540 residues), 449.5 bits, see alignment E=1.7e-138 PF01343: Peptidase_S49" amino acids 124 to 275 (152 residues), 94.8 bits, see alignment E=8.2e-31 amino acids 375 to 525 (151 residues), 172.3 bits, see alignment E=1.1e-54 TIGR00706: signal peptide peptidase SppA, 36K type" amino acids 305 to 523 (219 residues), 203.5 bits, see alignment E=2.9e-64 PF01972: SDH_sah" amino acids 333 to 413 (81 residues), 26 bits, see alignment E=6.9e-10

Best Hits

KEGG orthology group: K04773, protease IV [EC: 3.4.21.-] (inferred from 58% identity to pdi:BDI_3943)

Predicted SEED Role

"Protease IV"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (591 amino acids)

>HMPREF1078_RS05290 signal peptide peptidase SppA (Parabacteroides merdae CL09T00C40)
MKQFFKTVFASTLGVLVALGIVTMGSIFFIIGVAASADGSSEYKPDKNTVFKLSLDGVLV
DQAVKNPFSELMGESSNQMAVSDVIKAIRRAKANDNIKGIYLEAGSLSTGFAGIEAIRRE
LEDFKDSGKFIVSYGDYYTQGAYYLCSVADSVFLNPQGSVSLVGLASQGLFFTGLAEKIG
VEHYIFKVGTYKSAVEPFFLKKFSDANREQLTSFLGSVWGNLTTAIEKSRNISSDELDRY
LNEGLAMGQASNAVDYKLADGLRYRYEVENCVKEMAGQDVKGKLKTAGVDKIVSIKVKEK
ENKNKIAVLYAEGEIRDEDSSSPFSADEQVISEEMANKLRKLKDDDDVKAVVFRVNSPGG
SAYISEQIWKEVVELKAKKPIVVSMGNYAASGGYYISCAANKIVAERTTLTGSIGVFGVV
RNFTGTFDKVGVTTDIVKTNTFADLGDISRPMREDEKALIQRGVEQTYDLFLTRCADGRG
MTKAEIDSIGQGRVWTGEQALERGLVDQLGGMDDAIKEAATLAELTDYSVIVADGPKDFF
TKFMEKQMDEVKVSIAKSVMGEEQFKLFSTIRRAETESGIIARMPFDIKGL