Protein Info for HMPREF1078_RS04850 in Parabacteroides merdae CL09T00C40

Annotation: redox-sensing transcriptional repressor Rex

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 216 PF06971: Put_DNA-bind_N" amino acids 11 to 59 (49 residues), 68.4 bits, see alignment E=4.5e-23 PF02629: CoA_binding" amino acids 89 to 184 (96 residues), 68.5 bits, see alignment E=6.9e-23

Best Hits

Swiss-Prot: 72% identical to REX_BACTN: Redox-sensing transcriptional repressor Rex (rex) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K01926, AT-rich DNA-binding protein (inferred from 87% identity to pdi:BDI_2578)

Predicted SEED Role

"Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein)" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (216 amino acids)

>HMPREF1078_RS04850 redox-sensing transcriptional repressor Rex (Parabacteroides merdae CL09T00C40)
MANDEMKQIWKVPEPTLRRLPWYLAFLKLMKGRGEAFVSSTQIAKEINVDPSQVAKDLSF
VNISGKTRVGYEISTLVDVLEDFLGFTAQHKAFLFGVGSLGAALLQDSGLKQYGLEIVGG
FDVRRELAGTEINGIPVYHMDDFPAKQKEYGATIGVITVPVDKAQEVTELIIAGGIKALW
NFTPFRIRVPEDIVVQNTSMYAHLAVMFNRLNSINH