Protein Info for HMPREF1078_RS04715 in Parabacteroides merdae CL09T00C40

Annotation: GTPase HflX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 403 TIGR03156: GTP-binding protein HflX" amino acids 13 to 381 (369 residues), 437.2 bits, see alignment E=3.9e-135 PF13167: GTP-bdg_N" amino acids 31 to 118 (88 residues), 114.5 bits, see alignment E=8.2e-37 PF16360: GTP-bdg_M" amino acids 120 to 198 (79 residues), 111 bits, see alignment E=9.8e-36 PF00025: Arf" amino acids 197 to 332 (136 residues), 25.8 bits, see alignment E=2e-09 TIGR00231: small GTP-binding protein domain" amino acids 201 to 374 (174 residues), 48.6 bits, see alignment E=7.9e-17 PF01926: MMR_HSR1" amino acids 203 to 321 (119 residues), 83.2 bits, see alignment E=4.6e-27 PF02421: FeoB_N" amino acids 203 to 375 (173 residues), 27.5 bits, see alignment E=6.2e-10 PF00071: Ras" amino acids 204 to 380 (177 residues), 22.6 bits, see alignment E=2.1e-08

Best Hits

Swiss-Prot: 63% identical to HFLX_FLAPJ: GTPase HflX (hflX) from Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

KEGG orthology group: K03665, GTP-binding protein HflX (inferred from 94% identity to pdi:BDI_3288)

Predicted SEED Role

"GTP-binding protein HflX" in subsystem Hfl operon or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (403 amino acids)

>HMPREF1078_RS04715 GTPase HflX (Parabacteroides merdae CL09T00C40)
MKEFIISEAQTEKAVLVGLITPEQNEQKVKEYLDELAFLADTAGVEAVKRFYQKLDYPNS
VTFVGSGKLQEIKEYVVENEIGLVIFDDELSTKQLRNIEKELQVKILDRTNLILDIFARR
AQTAHAKTQVELAQYKYMLPRLTRLWTHLERQRGGVGMRGPGETQLETDKRIILDKISKL
KRDLVEIDKQKSVQRKNRGKMVRVALVGYTNVGKSTLMNLLSKSEVFAENKLFATLDTTV
RKVIVDNLPFLLSDTVGFIRKLPTELVESFKSTLDEVREADLLVHVVDISHPTFEEQIEV
VNRTLSEIDKTEKPMIMVFNKIDAFTFVPKDEDDLTPRTRENIDLDELKRTWMNKMQDNC
IFISAKERTNIDALKALLYERVKQIHITRFPYNDFLFQQYDEE