Protein Info for HMPREF1078_RS04490 in Parabacteroides merdae CL09T00C40

Annotation: ribonuclease Z

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 TIGR02651: ribonuclease Z" amino acids 5 to 301 (297 residues), 305.3 bits, see alignment E=1.9e-95 PF00753: Lactamase_B" amino acids 27 to 82 (56 residues), 27.4 bits, see alignment E=3.2e-10 PF12706: Lactamase_B_2" amino acids 35 to 155 (121 residues), 39 bits, see alignment E=7.1e-14

Best Hits

Swiss-Prot: 81% identical to RNZ_PARD8: Ribonuclease Z (rnz) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K00784, ribonuclease Z [EC: 3.1.26.11] (inferred from 81% identity to pdi:BDI_2651)

Predicted SEED Role

"Ribonuclease Z (EC 3.1.26.11)" in subsystem tRNA processing (EC 3.1.26.11)

Isozymes

Compare fitness of predicted isozymes for: 3.1.26.11

Use Curated BLAST to search for 3.1.26.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (304 amino acids)

>HMPREF1078_RS04490 ribonuclease Z (Parabacteroides merdae CL09T00C40)
MAEFNINILGCGSALPTTRHLATSQIVDLRDKLYMIDCGEGTQVQMRRMRVRFGRLAHIF
ISHLHGDHCFGLPGLISTLGMLGRTGELVVHGPKEVETYLRPVMDLFCRGMEFEVRFNPV
DTRSHSLVMEDRSLSVYSIPLKHRIPTCGYLFAEKPKEAHIIREMTDFYQVPVRCMKDIK
QGQDYVTPEGEVVPNSRLTRPATPPKRYACCSDTAYNRSIIPIIEGADLLYHEATFAECD
LARAKETFHSTARQAAEIARDAHVKRLVIGHYSARYEDLSELHREAEAVFPGTILGNEGT
VIPV