Protein Info for HMPREF1078_RS04335 in Parabacteroides merdae CL09T00C40

Annotation: family 20 glycosylhydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 31 to 159 (129 residues), 80.4 bits, see alignment E=4e-26 PF00728: Glyco_hydro_20" amino acids 163 to 509 (347 residues), 409.6 bits, see alignment E=2.7e-126 PF13290: CHB_HEX_C_1" amino acids 556 to 605 (50 residues), 29.1 bits, see alignment 1.6e-10 PF13287: Fn3_assoc" amino acids 557 to 615 (59 residues), 46.1 bits, see alignment 8.9e-16

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 55% identity to cpi:Cpin_1798)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (633 amino acids)

>HMPREF1078_RS04335 family 20 glycosylhydrolase (Parabacteroides merdae CL09T00C40)
MKKLLFIFFTAGLIQGFSSCSHKDTPDNALALIPQPQEMKVGTDHFKLTRRAAITLDTSN
PQLIGIARYFNNKVAPATGFEIPVEKHGNIEFKLTDNTAFGAEGYRLQVKHGDIIITAHQ
PAGIFYGIQTLLQMLPPEIKNSQKQKGIDWTVPCTDITDKPQFAWRGLMLDVSRHWFTKE
EVKKYIDELAEYKMNVFHWHLTDDQGWRLEIKSLPRLTEVGAWRAPRVGQWWQRAPQQPG
EETTYGGFYTQEDVKEVLAYAAERYVRVIPEIDVPGHSLAALVAYPDLACMKAPSAVGVG
NKFYGEDENTLCVGKDATFEFMDKVLTEVAALFPDEYIHIGGDECFKGFWHKCPRCQARM
KAENLKNENELQSYFIHRMESILKEKGKKLIGWDEIIDGGLAPDATVMSWRGMEGGIKSA
KAGHHVIMTPTEHCYIDLWQGEPSVEPDTYSMCRLKDSYSFNPVPDSVPAEMILGGQGNL
WAESVPTFRHAEYMTWPRGWALAEVLWTGPSKTDWDRFWPRVERHFVRADQAQINYARSM
YNAIVTPYYTEDGVLEIKLDSEPGNLDIYYTFDNTDPDNFTPKYEAPLRIPKNATWLRIV
TYRDNKPIGKVITLTIKELEKRADNTRHVVGNL