Protein Info for HMPREF1078_RS04095 in Parabacteroides merdae CL09T00C40

Annotation: cardiolipin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 transmembrane" amino acids 6 to 31 (26 residues), see Phobius details amino acids 41 to 61 (21 residues), see Phobius details TIGR04265: cardiolipin synthase" amino acids 10 to 479 (470 residues), 472.6 bits, see alignment E=8e-146 PF13396: PLDc_N" amino acids 22 to 63 (42 residues), 38.9 bits, see alignment 9.8e-14 PF13091: PLDc_2" amino acids 133 to 244 (112 residues), 54.8 bits, see alignment E=1.3e-18 amino acids 323 to 446 (124 residues), 104.7 bits, see alignment E=5.2e-34 PF00614: PLDc" amino acids 217 to 243 (27 residues), 31.4 bits, see alignment (E = 2.1e-11) amino acids 393 to 419 (27 residues), 35.3 bits, see alignment (E = 1.2e-12)

Best Hits

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 86% identity to pdi:BDI_2500)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>HMPREF1078_RS04095 cardiolipin synthase (Parabacteroides merdae CL09T00C40)
MLALIHIQWIVGIIFIILYCVTILGLVLVIITENRNPLKTIPWVIVLLLAPGIGLLFYFF
FGQDNRKQRIISRRTYKRIMKRPQEGKLPQDACSVPAPYQPLVTLLTNSNQSSLLYGSNI
TIYTNGADKFHDLLQEIAKATHHIHIQYYIFCDDEVGNKVKKLLIEKAKEGVEVRVLYDD
VGCWNVKDKFFKEMSDAGIEVHAFLKVAFPVFTSKVNYRNHRKIVVIDGKVGFMGGMNIA
DRYTKGTSWGTWRDTHFKIIGKGVHGLQAAFLIDWYVVSKKLLNEKIYYPPLPVYSDDNI
MQICTSGPVGQWRTLLQAAIFTVANAKKYVFIQTPYFLPTEGLNQALQIAALGGVDVRLM
LPKRSDTRTANMATHSFIDEMVKAGVKVYFYKPGFLHSKLMVADDELTCIGSANMDFRSF
EHNFEINAFVYQPSFAQQMRKVFLHDMHSCERLVPSRWLKRPLKQRIAESFMRLFSPLL