Protein Info for HMPREF1078_RS03615 in Parabacteroides merdae CL09T00C40

Annotation: anaerobic sulfatase-maturation protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 TIGR03942: anaerobic sulfatase maturase" amino acids 15 to 391 (377 residues), 482.5 bits, see alignment E=8.5e-149 PF04055: Radical_SAM" amino acids 20 to 189 (170 residues), 67.5 bits, see alignment E=1.7e-22 TIGR04085: radical SAM additional 4Fe4S-binding SPASM domain" amino acids 284 to 372 (89 residues), 65.6 bits, see alignment E=4.4e-22 PF13186: SPASM" amino acids 290 to 344 (55 residues), 36.6 bits, see alignment 4.6e-13

Best Hits

Swiss-Prot: 45% identical to ASLB_ECOLI: Anaerobic sulfatase-maturating enzyme homolog AslB (aslB) from Escherichia coli (strain K12)

KEGG orthology group: K06871, (no description) (inferred from 85% identity to pdi:BDI_0920)

Predicted SEED Role

"Putative arylsulfatase regulatory protein" in subsystem Alkanesulfonate assimilation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (411 amino acids)

>HMPREF1078_RS03615 anaerobic sulfatase-maturation protein (Parabacteroides merdae CL09T00C40)
MSNPYISPFAKPVYVMLKPVGSVCNLACEYCYYLEKGKLYPEVKNHIMSEQLLEKFIKEY
LECQTMPQVLFTWHGGETLMRPISFYRKALELQRKYGHRRQIDNCIQTNGTLLNDDWCRF
FKENNFLVGVSIDGPQEFHDEYRRNKQGLPSFYKVMKGIELLKKHGVEYNAMAVVNDYNV
DYPLEFYHFFKEIDCHYIQFTPIVERLGFHQDGTLLTSPEQQDANIKLAPFTVNAGKWGD
FLCAVFDEWLKEDVGNYYIQLFDSTLANWVGEQPGVCTLARTCGHAGVMEFNGDVYACDH
FVFPEYKLGNIHTQTLTEMMYSQRQLKFGADKYETLPTQCKECDYLFACNGECPKNRFLH
TANGEPGLNYLCRGYKKFFKHVAPYMDFMKKELLAERPPANVMQWAKENKL