Protein Info for HMPREF1078_RS02450 in Parabacteroides merdae CL09T00C40

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 PF00815: Histidinol_dh" amino acids 18 to 426 (409 residues), 572.1 bits, see alignment E=3.8e-176 TIGR00069: histidinol dehydrogenase" amino acids 30 to 425 (396 residues), 535.2 bits, see alignment E=5.9e-165

Best Hits

Swiss-Prot: 71% identical to HISX_BACTN: Histidinol dehydrogenase (hisD) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 86% identity to pdi:BDI_0967)

MetaCyc: 52% identical to histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655)
Histidinol dehydrogenase. [EC: 1.1.1.23]

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (429 amino acids)

>HMPREF1078_RS02450 histidinol dehydrogenase (Parabacteroides merdae CL09T00C40)
MEVIKYPSREEWASLALRPALDVTTLFDTVRTVLDEVRKGGDAAVIRYEEKFDKIDPATF
KRLQVSEQELAEAKELVPEELKQAIRQAKNNIEIFHASQRFTGKKVETTPGVTCWQKAVA
IEKVGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPGKDGKVHPAILFAAETAGVS
KIFKAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEV
IADESANPAFIAADFLSQAEHGVDSQAMLVTASESIVEPIMQAIREQLDRLPRKEITEKS
LSHSRLIVLKDKQEVIDFTNLYAPEHLIIQTTDYADIAGQVENAGSVFMGSYTPESAGDY
ASGTNHTLPTNGYAKAYSGVNLDSFIKKITFQEITADGIRLLGGTIRTMAANEQLDAHKN
AVTIRLNTL