Protein Info for HMPREF1078_RS02335 in Parabacteroides merdae CL09T00C40

Annotation: type II pantothenate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03630: Fumble
  • amino acids 101 to 232 (132 residues), 83.9 bits, E=1.2e-27

Best Hits

KEGG orthology group: K09680, type II pantothenate kinase [EC: 2.7.1.33] (inferred from 74% identity to bvu:BVU_3836)

Predicted SEED Role

"Pantothenate kinase type II, eukaryotic (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• phosphopantothenate biosynthesis I (4/4 steps found)
• phosphopantothenate biosynthesis II (1/3 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (4/10 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.33

Use Curated BLAST to search for 2.7.1.33

Protein Sequence (280 amino acids)

>HMPREF1078_RS02335 type II pantothenate kinase (Parabacteroides merdae CL09T00C40)
MGVVIGIDVGGSTTKIIGVENKSIQSPMFVKATDPVTSLFGAFGKYIYDNGITLPEIEMV
MLTGVGSAFIDQPLYGLPTAKTDEFLANGLGAKYTASLENLIVVSMGTGTSFVKVEGPHI
QHIGGIGIGGGTLLGLSRLLLKTQDIHLIAEMARKGTLTNIDLQIQDICNRPLPDLPLDA
TASNFGKADGNASPEDIASGIIHMVLQSIGQAAILSALNSPIRNFVLIGNLTQLPQCKEI
FPKLEEMYGVRFLIPKYSEYRTAIGAALTYMDGAPIHPIK