Protein Info for HMPREF1078_RS02070 in Parabacteroides merdae CL09T00C40

Annotation: folylpolyglutamate synthase/dihydrofolate synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 transmembrane" amino acids 413 to 431 (19 residues), see Phobius details TIGR01499: bifunctional protein FolC" amino acids 34 to 427 (394 residues), 357 bits, see alignment E=8.6e-111 PF08245: Mur_ligase_M" amino acids 51 to 228 (178 residues), 48.2 bits, see alignment E=6.6e-17

Best Hits

KEGG orthology group: K11754, dihydrofolate synthase / folylpolyglutamate synthase [EC: 6.3.2.12 6.3.2.17] (inferred from 57% identity to bsa:Bacsa_0917)

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.12 or 6.3.2.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (435 amino acids)

>HMPREF1078_RS02070 folylpolyglutamate synthase/dihydrofolate synthase family protein (Parabacteroides merdae CL09T00C40)
MTYEETLHYLYTSIPVFQNAGPSAYKPGLGTSIALDDHLGNPHKAYKTIHVAGTNGKGSV
SHLLAAILRQSGYKVGLYTSPHLVDFRERIRVNGQKIPEEYVIDFVERHRSFFETLDPSF
FELTSSMAFDYFRAEKVDYAVIEVGMGGRLDSTNIITPILSIITNISLDHTQFLGDTVEK
IAFEKAGIIKKDVPALVGEIDRHSVAQVFADAAVKAGTLVYFAQDEGLLKESYLMDTGEW
YLDSAEYGQLFGELGGVVQFRNATTVLGAINLLNTVGVNIPTEAVREGFEHVVELTGLMG
RWQVLQENPKVVCDTGHNVGGWQYLNIQLEEELKRHKHLFMIVGMVNDKDIDGVLDLMPE
KAFYFFTQASVQRAMPAEDFATKAIFHGLSGTICNSVQEAVEKALARAGQDDIIFIGGST
FVVADALPLFLKRDK