Protein Info for HMPREF1078_RS01370 in Parabacteroides merdae CL09T00C40

Annotation: alkaline phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 564 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00245: Alk_phosphatase" amino acids 30 to 466 (437 residues), 204.1 bits, see alignment E=3.8e-64

Best Hits

KEGG orthology group: K01077, alkaline phosphatase [EC: 3.1.3.1] (inferred from 79% identity to pdi:BDI_0912)

Predicted SEED Role

"Alkaline phosphatase (EC 3.1.3.1)" in subsystem Phosphate metabolism (EC 3.1.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.1

Use Curated BLAST to search for 3.1.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (564 amino acids)

>HMPREF1078_RS01370 alkaline phosphatase (Parabacteroides merdae CL09T00C40)
MKKTISLLLLLSVIFMPVKAQDVENVKPVKNVILLIPDGTSLATVSMARWLQWYTNPDKP
KLNIDPYLCGTVRTHSSNAPIGDSAPTTSCYMTGQPSRTGYVSTYPENDGDNDIYPTDPA
RAFQPLTTVLEAAKIKQGKSTGLVFTCEFPHATPADCSAHSYNRGKYEWIAPQMAHNDLN
VVIGGGASLLPEESEAYLKGNGYGIFKNDIDGMRNYKGNNMWALFGDREMAYDIDRDPSQ
QPSLEEMTRKAIEKLSQNPNGFFLMVEGSKVDWAAHANDPVGMATDMLAFDRACGAALEF
ARQNGETAVVIVPDHGNSGISIGRADCKGYDKLSKDQLFHQLSLYKLTAEGFAKKVNSVP
NSEVQNVFREYAGFELTPEELDALNHCKNYKNSPIPENERSIEGKGSLYSSSLTTFMSKL
LTSRTCFGFTTGGHTGEEVFLAAYHPDRTSLPLGMHTNIELNHYLCALFGMTHDTLEELT
TGNFAPHTEVFKDFKCEIVPAKDEKGSPSLVVKNKRKQINITPFSNIVTIGKKGREEIRL
NSVIVYVDKNNTFYLPTKLAEYLQ