Protein Info for HMPREF1078_RS01290 in Parabacteroides merdae CL09T00C40
Annotation: hypothetical protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 87% identity to pdi:BDI_0578)Predicted SEED Role
"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (18/21 steps found)
- superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (20/26 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.14
Use Curated BLAST to search for 2.4.2.14
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (630 amino acids)
>HMPREF1078_RS01290 hypothetical protein (Parabacteroides merdae CL09T00C40) MEVLKHECGVAMVRLLKPLEYYHQKYGTWMYGLNKLYLLMEKQHNRGQEGAGLACVKLEA SPGEEYMFRERALGTEAITEIFAAVHEYYKDLPPDKLNDPLFAKTNLPFAGELYMGHLRY STTGKSGISYVHPFLRRNNWRAKNLALCGNFNLTNVQDIFEEITAIGQHPRAYADTFIML EQVGHRLDREVERLYRKYEAEGLKGMNITHAIEANVDLSNVLKRCAPQWDGGFVICGLTG SGESFSVRDPWGIRPAFYYADDEIVILASERPVIQTAMNVPAEDVHELKRGEALIINKQG DWHTSQIMEPKENKACSFERIYFSRGSDRDIYRERKRLGENLVPAVLKAVDNDLNHTVFS FIPNTAEVAYFGLQEGMNEYLNKKKKEWIADRSHLLQEEELEQILSMRVRCEKVAIKDIK LRTFIAEGNSRNDLAAHVYDITYGSVVPFEDNLVVIDDSIVRGTTLRQSIIGILDRLNPK KIVVVSSSPQVRYPDYYGIDMSRMSEFIAFKAAVALLVDKGMESVLLDAYKKAKRQQVMP CDATVNCVKEIYASFTDEEISAKMVELLTPVGTRAKVEIVYQTLEGLHAACPDHPGDWYF SGDYPTPGGVRMVNEAFIHYMEEEYWGIEK