Protein Info for HMPREF1078_RS00930 in Parabacteroides merdae CL09T00C40

Annotation: cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 PF13500: AAA_26" amino acids 8 to 236 (229 residues), 53.9 bits, see alignment E=3.2e-18 PF01656: CbiA" amino acids 8 to 237 (230 residues), 62.7 bits, see alignment E=5.2e-21 TIGR00313: cobyric acid synthase CobQ" amino acids 8 to 501 (494 residues), 482.9 bits, see alignment E=5.6e-149 PF07685: GATase_3" amino acids 259 to 458 (200 residues), 161 bits, see alignment E=4.2e-51

Best Hits

Swiss-Prot: 85% identical to COBQ_PARD8: Cobyric acid synthase (cobQ) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 85% identity to pdi:BDI_1360)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (507 amino acids)

>HMPREF1078_RS00930 cobyric acid synthase (Parabacteroides merdae CL09T00C40)
MNVRLKPIMFVGTCSDAGKSVINAAFCRIFKQDGYHPAPFKAQNMSLNSYSTPEGGEMGR
AQVVQAEACGIAPHTDMNPVLLKPTNDKSSQVVLNGRPVGNMSAQDYFGMQNQKEVLFKE
AIEAFHRLESRYSPIVLEGAGSISELNLRDRDITNMRMAEQAGAATFLVADIDRGGVFGS
VYGTIALLKPEERVLMKGIIINKFRGDASLFDDGRKIIEDLTGVPVVGVIPWFRDIKIEE
EDSVALDMKHNTYRDGKINVAIILLKRMSNFTDFDVLDMDPRFNAYYTNNIDEIEKADII
LLPGSKNTLSDLQSLRACGIADAIIRAHKNGKKVIGICGGYQMMGARLEDPKAIEGNLPA
VPGLGLLPQCTIIEPEKITRQSTFAFLPGLCKDGSCKSGSRTISYGCRGYEIHMGRTTLL
GDAPENPVAVLNDGRTDGYYLDNTCWGSYMHGILDNPEVLDNLAEGFDKETTDHPFDYAA
FKEEQYDKLANLVRKHVDMDYIYRQLV