Protein Info for HMPREF1078_RS00855 in Parabacteroides merdae CL09T00C40

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 69 to 88 (20 residues), see Phobius details amino acids 108 to 127 (20 residues), see Phobius details amino acids 138 to 157 (20 residues), see Phobius details amino acids 166 to 186 (21 residues), see Phobius details amino acids 192 to 209 (18 residues), see Phobius details amino acids 217 to 232 (16 residues), see Phobius details amino acids 238 to 255 (18 residues), see Phobius details amino acids 317 to 339 (23 residues), see Phobius details amino acids 346 to 370 (25 residues), see Phobius details amino acids 386 to 409 (24 residues), see Phobius details amino acids 423 to 441 (19 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 14 to 441 (428 residues), 450.3 bits, see alignment E=2.5e-139 TIGR00773: Na+/H+ antiporter NhaA" amino acids 21 to 441 (421 residues), 367.1 bits, see alignment E=5e-114

Best Hits

Swiss-Prot: 81% identical to NHAA_PARD8: Na(+)/H(+) antiporter NhaA (nhaA) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 81% identity to pdi:BDI_0928)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>HMPREF1078_RS00855 Na+/H+ antiporter NhaA (Parabacteroides merdae CL09T00C40)
MDRTINVILKPLRRFAMQKPNASILLFMAMILAMLFANSPWAESYHNILSHPIDLKIGNF
TPFMHHGEVMPMLVFVNDALMAVFFFVIGLEIKQEILIGELSSVRKALLPIIAACGGMIV
PVLFYFLVCHSAPEVRGVAIPMATDIAFALAVLGLLGKRVPLSMRIFLTALAVVDDIGGI
IIIALFYSGEIAFEPLLISLALLALLYVGGRMRVNNIAFYYIIGFFVWMLFLESGIHPTI
AGVLVAFTVPARPVVKLDDFTCEMTGYLDMLDYTEVRHSRKAAVLSSTQIQVLNNIHSLA
DKTISPLQSIANKLHPLVNYLILPLFAFVNAGVTFGDIGIGSLLGIPLAVFFGLFAGKSL
GIFLFTYIFVRLRLATMPEGVSKRNLFGVSMLGGIGFTVALFIANLSFAGMPDVGVELLN
QAKLGVFAGSFISGLCGYLILKKVLPKNYRDGQT